Gheorghe Liliana, Nemteanu Roxana, Clim Andreea, Botnariu Gina Eosefina, Costache Irina Iuliana, Plesa Alina
Department of Radiology, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Radiology Clinic, "St. Spiridon" County Clinical Emergency Hospital, 700111 Iasi, Romania.
Life (Basel). 2023 Mar 23;13(4):857. doi: 10.3390/life13040857.
Over the past 100 years, cardiovascular disease (CVD) has become a leading cause of mortality and morbidity in developed countries, and similar trends have occurred for chronic liver disease. Subsequent research also indicated that people with non-alcoholic fatty liver disease (NAFLD) had a twofold increased risk of CV events and that this risk was doubled in those with liver fibrosis. However, no validated CVD risk score specific for NAFLD patients has yet been validated, as traditional risk scores tend to underestimate the CV risk in NAFLD patients. From a practical perspective, identifying NAFLD patients and assessing severity of liver fibrosis when concurrent atherosclerotic risk factors are already established may serve as an important criterion in new CV risk scores. The current review aims to assess current risk scores and their utility for the prediction of CV events among patients with NAFLD.
在过去的100年里，心血管疾病（CVD）已成为发达国家死亡和发病的主要原因，慢性肝病也出现了类似的趋势。随后的研究还表明，非酒精性脂肪性肝病（NAFLD）患者发生心血管事件的风险增加了两倍，而在肝纤维化患者中这一风险则增加了一倍。然而，目前尚未有经过验证的针对NAFLD患者的心血管疾病风险评分，因为传统风险评分往往低估了NAFLD患者的心血管风险。从实际角度来看，当并发动脉粥样硬化风险因素已经确定时，识别NAFLD患者并评估肝纤维化的严重程度可能是新的心血管疾病风险评分的一个重要标准。本综述旨在评估当前的风险评分及其在预测NAFLD患者心血管事件方面的效用。
