从藿香蓟中分离出的一种新色烯。

A new chromene isolated from Ageratum conyzoides.

作者信息

Adebayo Abiodun Humphrey, Jig Chang-Jiu, Zhang Yu-Mei, He Wen-Jun, Zeng Guang-Zhi, Han Hong-Jin, Xu Jun-Ju, Akindahunsi Afolabi Akintunde, Tana Ning-Hua

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

出版信息

Nat Prod Commun. 2011 Sep;6(9):1263-5.

PMID:21941894

Abstract

From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested.

摘要

从藿香蓟（菊科）全草的乙醇提取物中分离得到一个新的色烯，即2,2 - 二甲基色烯7 - 甲氧基 - 6 - O - β - D - 吡喃葡萄糖苷，以及13个已知化合物，其中7个为首次报道。这些化合物均通过质谱、红外光谱、一维和二维核磁共振光谱进行表征。7,3',5'-三 - O - 甲基三羟黄酮（7）、早熟素II（9）、3,5,7,4'-四羟基黄酮（13）和5,6,7,3',4',5'-六甲氧基黄酮（14）对P - 388癌细胞系表现出抑制活性，IC50值分别为12.8、24.8、3.5和7.8微摩尔，而化合物9对HT - 29癌细胞系表现出抑制活性，IC50值为61微摩尔；其他化合物在测试的细胞系中未显示出明显的细胞毒性活性。