Adebayo Abiodun Humphrey, Jig Chang-Jiu, Zhang Yu-Mei, He Wen-Jun, Zeng Guang-Zhi, Han Hong-Jin, Xu Jun-Ju, Akindahunsi Afolabi Akintunde, Tana Ning-Hua
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
Nat Prod Commun. 2011 Sep;6(9):1263-5.
From the ethanol extract of the whole plant of Ageratum conyzoides L. (Compositae), one new chromene, 2,2-dimethylchromene 7-methoxy-6-O-beta-D-glucopyranoside, was isolated, together with thirteen known compounds, seven of which were being reported for the first time. The compounds were all characterized by MS, IR, 1D- and 2D-NMR spectroscopy. 7,3',5'-Tri-O-methyltricetin (7), precocene II (9), 3,5,7,4'-tetrahydroxyflavone (13) and 5,6,7,3',4',5'-hexamethoxyflavone (14) exhibited inhibitory activity on the P-388 cancer cell line with IC50 values of 12.8, 24.8, 3.5 and 7.8 microM respectively, while compound 9 exhibited inhibitory activity on the HT-29 cancer cell line with an IC50 value of 61 microM; the others showed no significant cytotoxic activity on the cell lines tested.
从藿香蓟（菊科）全草的乙醇提取物中分离得到一个新的色烯，即2,2 - 二甲基色烯7 - 甲氧基 - 6 - O - β - D - 吡喃葡萄糖苷，以及13个已知化合物，其中7个为首次报道。这些化合物均通过质谱、红外光谱、一维和二维核磁共振光谱进行表征。7,3',5'-三 - O - 甲基三羟黄酮（7）、早熟素II（9）、3,5,7,4'-四羟基黄酮（13）和5,6,7,3',4',5'-六甲氧基黄酮（14）对P - 388癌细胞系表现出抑制活性，IC50值分别为12.8、24.8、3.5和7.8微摩尔，而化合物9对HT - 29癌细胞系表现出抑制活性，IC50值为61微摩尔；其他化合物在测试的细胞系中未显示出明显的细胞毒性活性。
