Adeyemi Olufunmilayo Olaide, Adeneye Adejuwon Adewale, Alabi Tope Elizabeth
Department of Pharmacology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria.
Indian J Exp Biol. 2011 Sep;49(9):698-703.
The analgesic effect and possible mechanism(s) of action of 50-200 mg/kg of the aqueous seed extract of H. umbellata (HU) were investigated in different experimental models of analgesia using the tail flick, tail immersion, acetic acid-induced writhing tests and formalin-induced algesia. Oral pre-treatment with 50-200 mg/kg of HU caused significant and dose related analgesic effect in the treated rats in all the experimental models used. This analgesia was mediated via central and peripheral mechanisms. Overall, the results showed that HU possesses analgesic effect which lends support to its folkloric use in the local management of pain.
使用甩尾、尾浸、醋酸诱导扭体试验和福尔马林诱导痛觉过敏等不同的镇痛实验模型，研究了50 - 200 mg/kg伞房花耳草水种子提取物（HU）的镇痛作用及其可能的作用机制。在所有使用的实验模型中，对大鼠口服给予50 - 200 mg/kg的HU进行预处理后，产生了显著的、与剂量相关的镇痛效果。这种镇痛作用是通过中枢和外周机制介导的。总体而言，结果表明HU具有镇痛作用，这为其在当地疼痛管理中的民间应用提供了支持。
