Ivanov V V, Lusta I V, Satrikhina T N, Udintsev N A
Probl Endokrinol (Mosk). 1990 Mar-Apr;36(2):77-80.
The development of emotional pain stress in rats is accompanied by an increase in lipid peroxidation (LPO) products in the pancreas and a decrease in antiradical activity of its lipids. Hypoinsulinemia, of which a degree of expression is inversely proportional to an increase in peroxidation products, is observed. Antioxidant administration prevents LPO process activation in the pancreas and inhibits, to a great extent, a decrease in the level of insulin in stress. It is assumed that a certain role in the development of hypoinsulinemia in stress can be played by LPO processes resulting in the formation of active forms of oxygen and damage of the islands of Langerhans of B-cells.
大鼠情绪性疼痛应激的发展伴随着胰腺中脂质过氧化（LPO）产物的增加及其脂质抗自由基活性的降低。观察到存在低胰岛素血症，其表达程度与过氧化产物的增加呈反比。给予抗氧化剂可防止胰腺中LPO过程的激活，并在很大程度上抑制应激状态下胰岛素水平的降低。据推测，应激状态下低胰岛素血症的发展中，LPO过程可能起到一定作用，该过程导致活性氧形式的形成以及胰岛β细胞的损伤。
