全基因组代谢网络重建与基于约束的建模。
Whole-genome metabolic network reconstruction and constraint-based modeling.
作者信息
Haggart Charles R, Bartell Jennifer A, Saucerman Jeffrey J, Papin Jason A
机构信息
Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
出版信息
Methods Enzymol. 2011;500:411-33. doi: 10.1016/B978-0-12-385118-5.00021-9.
Abstract
With the advent of modern high-throughput genomics, there is a significant need for genome-scale analysis techniques that can assist in complex systems analysis. Metabolic genome-scale network reconstructions (GENREs) paired with constraint-based modeling are an efficient method to integrate genomics, transcriptomics, and proteomics to conduct organism-specific analysis. This text explains key steps in the GENRE construction process and several methods of constraint-based modeling that can help elucidate basic life processes and development of disease treatment, bioenergy solutions, and industrial bioproduction applications.
摘要
随着现代高通量基因组学的出现，迫切需要能够辅助复杂系统分析的基因组规模分析技术。代谢基因组规模网络重建（GENREs）与基于约束的建模相结合，是整合基因组学、转录组学和蛋白质组学以进行特定生物体分析的有效方法。本文解释了GENRE构建过程中的关键步骤以及几种基于约束的建模方法，这些方法有助于阐明基本生命过程以及疾病治疗、生物能源解决方案和工业生物生产应用的发展。
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