Grunhagen Thijs, Shirazi-Adl Aboulfazl, Fairbank Jeremy C T, Urban Jill P G
Department of Physiology, Anatomy and Genetics, Oxford University, Oxford, UK.
Orthop Clin North Am. 2011 Oct;42(4):465-77, vii. doi: 10.1016/j.ocl.2011.07.010.
The biomechanical behavior of the intervertebral disk ultimately depends on the viability and activity of a small population of resident cells that make and maintain the disk's extracellular matrix. Nutrients that support these cells are supplied by the blood vessels at the disks' margins and diffuse through the matrix of the avascular disk to the cells. This article reviews pathways of nutrient supply to these cells; examines factors that may interrupt these pathways, and discusses consequences for disk cell survival, disk degeneration, and disk repair.
椎间盘的生物力学行为最终取决于一小群驻留细胞的活力和活性，这些细胞制造并维持椎间盘的细胞外基质。支持这些细胞的营养物质由椎间盘边缘的血管供应，并通过无血管椎间盘的基质扩散到细胞。本文综述了这些细胞的营养供应途径；研究了可能中断这些途径的因素，并讨论了对椎间盘细胞存活、椎间盘退变和椎间盘修复的影响。
