Cheung Gary, Stapelberg Janli
Mental Health Services for Older People, Auckland District Health Board, Private Bag 92189, Greenlane Clinical Centre, Auckland, New Zealand.
N Z Med J. 2011 Jun 10;124(1336):39-50.
This meta-analysis is aimed to determine the efficacy of quetiapine for the treatment of behavioural and psychological symptoms of dementia (BPSD).
Our electronic search included MEDLINE (1950-2009), Cochrane Central Register of Controlled Trials and PsychINFO. We also did a hand search of the International Psychogeriatric Association poster presentations and checked the National trial registry data bases from USA, UK, RSA, Holland, Australia and New Zealand. We included double-blinded randomised placebo-controlled trials studies that measured BPSD with the Neuropsychiatric Inventory (NPI). The Clinical Global Impression of Change scale (CGI-C) was our secondary outcome.
Six sets of data were included in this meta-analysis. Patients receiving quetiapine improved when compared to placebo with a weighted mean difference of - 3.05 (95% CI: -6.10, -0.01) and -0.31 (95% CI: -0.54, -0.08) respectively on the NPI score and CGI-C score.
This meta-analysis found that quetiapine is statistically more efficacious than placebo in the treatment of BPSD as measured by the NPI and CGI-C. However, improvement is of a small magnitude and observable clinical significance is questionable.
本荟萃分析旨在确定喹硫平治疗痴呆行为和心理症状（BPSD）的疗效。
我们的电子检索包括MEDLINE（1950 - 2009年）、Cochrane对照试验中心注册库和PsychINFO。我们还对国际老年精神病学协会的海报展示进行了手工检索，并检查了美国、英国、南非、荷兰、澳大利亚和新西兰的国家试验注册数据库。我们纳入了采用神经精神科问卷（NPI）测量BPSD的双盲随机安慰剂对照试验研究。临床总体印象变化量表（CGI - C）是我们的次要结局指标。
本荟萃分析纳入了六组数据。与安慰剂相比，接受喹硫平治疗的患者在NPI评分和CGI - C评分上分别有改善，加权平均差分别为 - 3.05（95%可信区间：- 6.10，- 0.01）和 - 0.31（95%可信区间：- 0.54，- 0.08）。
本荟萃分析发现，以NPI和CGI - C衡量，喹硫平在治疗BPSD方面在统计学上比安慰剂更有效。然而，改善程度较小，可观察到的临床意义值得怀疑。
