美国国立卫生研究院（NIH）在癫痫研究方面的资金投入存在差异。
Disparities in NIH funding for epilepsy research.
机构信息
Department of Neurology, Emory University, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA.
出版信息
Neurology. 2011 Sep 27;77(13):1305-7. doi: 10.1212/WNL.0b013e318230a18f.
Abstract
Using data from NIH Research Portfolio Online Reporting Tools (RePORT) and recently assembled prevalence estimates of 6 major neurologic diseases, we compared the relative prevalences and the annual NIH support levels for 6 major neurologic disorders: Alzheimer disease, amyotrophic lateral sclerosis (ALS), epilepsy, multiple sclerosis, Parkinson disease, and stroke. Compared to these other major neurologic disorders, epilepsy research is funded at a persistently lower rate based on relative disease prevalences. Relative NIH funding for these other disorders in 2010 adjusted for prevalence ranged from 1.7x (stroke) to 61.1x (ALS) greater than epilepsy. The disparity cannot be explained by differences in the overall impact of these diseases on US citizens. Greater transparency in the review and funding process is needed to disclose the reason for this disparity.
摘要
利用美国国立卫生研究院研究组合在线报告工具（RePORT）的数据和最近汇总的 6 种主要神经疾病的流行率估计，我们比较了 6 种主要神经疾病（阿尔茨海默病、肌萎缩性侧索硬化症、癫痫、多发性硬化症、帕金森病和中风）的相对流行率和美国国立卫生研究院每年的支持水平。与这些其他主要神经疾病相比，癫痫研究的资金支持率一直基于相对疾病流行率较低。2010 年，根据流行率调整后的这些其他疾病的相对 NIH 资金支持范围从癫痫的 1.7 倍（中风）到 61.1 倍（肌萎缩性侧索硬化症）不等。这种差异不能用这些疾病对美国公民的总体影响的差异来解释。需要提高审查和资助过程的透明度，以揭示这种差异的原因。
相似文献
1
Disparities in NIH funding for epilepsy research.美国国立卫生研究院（NIH）在癫痫研究方面的资金投入存在差异。
Neurology. 2011 Sep 27;77(13):1305-7. doi: 10.1212/WNL.0b013e318230a18f.
2
Disparities in NIH funding for epilepsy research.美国国立卫生研究院（NIH）对癫痫研究的资金投入差异。
Neurology. 2012 Jan 24;78(4):292-3; author reply 293-4. doi: 10.1212/WNL.0b013e3182475126.
3
National Institutes of Health Funding to Departments of Orthopaedic Surgery at U.S. Medical Schools.美国国立卫生研究院对美国医学院校骨科手术科室的资助。
J Bone Joint Surg Am. 2017 Jan 18;99(2):e5. doi: 10.2106/JBJS.16.00088.
4
The state of research funding from the National Institutes of Health for criminal justice health research.美国国立卫生研究院用于刑事司法健康研究的研究资金状况。
Ann Intern Med. 2015 Mar 3;162(5):345-52. doi: 10.7326/M14-2161.
5
Comparing cutaneous research funded by the US National Institutes of Health (NIH) with the US skin disease burden.比较美国国立卫生研究院（NIH）资助的皮肤研究与美国皮肤疾病负担。
J Am Acad Dermatol. 2015 Sep;73(3):383-91.e1. doi: 10.1016/j.jaad.2015.04.039. Epub 2015 Jun 4.
6
NIH disease funding levels and burden of disease.NIH 疾病资助水平与疾病负担。
PLoS One. 2011 Feb 24;6(2):e16837. doi: 10.1371/journal.pone.0016837.
7
Patterns of Recent National Institutes of Health (NIH) Funding to Diagnostic Radiology Departments: Analysis Using the NIH RePORTER System.美国国立卫生研究院（NIH）近期对诊断放射科的资助模式：使用NIH RePORTER系统进行分析
Acad Radiol. 2017 Sep;24(9):1162-1168. doi: 10.1016/j.acra.2017.02.018. Epub 2017 May 18.
8
NIH funding trajectories and their correlations with US health dynamics from 1950 to 2004.1950年至2004年美国国立卫生研究院（NIH）的资金投入轨迹及其与美国健康动态的相关性。
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):10981-6. doi: 10.1073/pnas.0905104106. Epub 2009 Jun 22.
9
Trends in Health Disparities, Health Inequity, and Social Determinants of Health Research: A 17-Year Analysis of NINR, NCI, NHLBI, and NIMHD Funding.健康差异、健康不平等及健康研究的社会决定因素趋势：对美国国立护理研究院、国立癌症研究所、国立心肺血液研究所及国立少数族裔健康与健康不平等研究所17年资助情况的分析
Nurs Res. 2018 May/Jun;67(3):231-241. doi: 10.1097/NNR.0000000000000278.
10
Recent trends in National Institutes of Health funding for surgery: 2003 to 2013.美国国立卫生研究院2003年至2013年手术领域的资助趋势
Am J Surg. 2015 Jun;209(6):1083-9. doi: 10.1016/j.amjsurg.2015.01.015. Epub 2015 Mar 21.
引用本文的文献
1
A research roadmap for SCN8A-related disorders: addressing knowledge gaps and aligning research priorities across stakeholders.一份关于与SCN8A相关疾病的研究路线图：填补知识空白并协调各利益相关方的研究重点。
Orphanet J Rare Dis. 2025 Aug 19;20(1):444. doi: 10.1186/s13023-025-03672-w.
2
Family reflections: a candid view from caretakers of patients with pediatric epilepsy.家庭反思：来自小儿癫痫患者照料者的真实看法。
Pediatr Res. 2024 Jun 27. doi: 10.1038/s41390-024-03276-3.
3
What the Top Ten epilepsy research priorities mean for the UK research ecosystem.十大癫痫研究重点对英国研究生态系统意味着什么。
EBioMedicine. 2024 Feb;100:104919. doi: 10.1016/j.ebiom.2023.104919. Epub 2024 Jan 10.
4
Health Disparities in Pediatric Epilepsy: Methods and Lessons Learned.儿科癫痫的健康差异：方法和经验教训。
J Clin Psychol Med Settings. 2023 Jun;30(2):251-260. doi: 10.1007/s10880-022-09898-1. Epub 2022 Aug 5.
5
Underutilization of epilepsy surgery: Part II: Strategies to overcome barriers.癫痫手术利用不足：第二部分：克服障碍的策略。
Epilepsy Behav. 2021 Apr;117:107853. doi: 10.1016/j.yebeh.2021.107853. Epub 2021 Mar 4.
6
Underutilization of epilepsy surgery: Part I: A scoping review of barriers.癫痫手术利用不足：第一部分：障碍的范围综述。
Epilepsy Behav. 2021 Apr;117:107837. doi: 10.1016/j.yebeh.2021.107837. Epub 2021 Feb 18.
7
Investigating imaging network markers of cognitive dysfunction and pharmacoresistance in newly diagnosed epilepsy: a protocol for an observational cohort study in the UK.研究新诊断癫痫患者认知功能障碍和药物抵抗的影像学网络标志物：英国观察性队列研究方案。
BMJ Open. 2019 Oct 16;9(10):e034347. doi: 10.1136/bmjopen-2019-034347.
8
The challenge and promise of anti-epileptic therapy development in animal models.在动物模型中开发抗癫痫治疗的挑战与前景。
Lancet Neurol. 2014 Sep;13(9):949-60. doi: 10.1016/S1474-4422(14)70076-6. Epub 2014 Aug 10.
9
Sociology: Shedding the shame.社会学：摆脱羞耻感。
Nature. 2014 Jul 10;511(7508):S10-1. doi: 10.1038/511s10a.
10
Development of lacosamide for the treatment of partial-onset seizures.拉考沙胺治疗部分发作性癫痫的研究进展。
Ann N Y Acad Sci. 2013 Jul;1291(1):56-68. doi: 10.1111/nyas.12213.
本文引用的文献
1
The long-term risk of premature mortality in people with epilepsy.癫痫患者过早死亡的长期风险。
Brain. 2011 Feb;134(Pt 2):388-95. doi: 10.1093/brain/awq378.
2
The social and economic consequences of epilepsy: a controlled national study.癫痫的社会和经济后果：一项全国对照研究。
Epilepsia. 2011 May;52(5):949-56. doi: 10.1111/j.1528-1167.2010.02946.x. Epub 2011 Jan 28.
3
Temporal trends in the mortality of people with epilepsy: a review.癫痫患者死亡率的时间趋势：综述。
Epilepsia. 2010 Nov;51(11):2241-6. doi: 10.1111/j.1528-1167.2010.02711.x. Epub 2010 Sep 24.
4
Long-term mortality in childhood-onset epilepsy.儿童期起病癫痫的长期死亡率。
N Engl J Med. 2010 Dec 23;363(26):2522-9. doi: 10.1056/NEJMoa0911610.
5
Cognitive consequences of childhood-onset temporal lobe epilepsy across the adult lifespan.儿童期起病颞叶癫痫对成年后认知的影响。
Neurology. 2010 Aug 24;75(8):705-11. doi: 10.1212/WNL.0b013e3181eee3f0.
6
Suicide and epilepsy.自杀与癫痫
Curr Opin Neurol. 2009 Apr;22(2):174-8. doi: 10.1097/WCO.0b013e328328f8c3.
7
Psychiatric comorbidities in epilepsy.癫痫中的精神共病
Int Rev Neurobiol. 2008;83:347-83. doi: 10.1016/S0074-7742(08)00020-2.
8
Quality-of-life trajectories in epilepsy: a review of the literature.癫痫患者的生活质量轨迹：文献综述
Epilepsy Behav. 2008 May;12(4):557-71. doi: 10.1016/j.yebeh.2007.11.013. Epub 2007 Dec 26.
9
How common are the "common" neurologic disorders?“常见”的神经系统疾病有多常见？
Neurology. 2007 Jan 30;68(5):326-37. doi: 10.1212/01.wnl.0000252807.38124.a3.
10
Cognitive prognosis in chronic temporal lobe epilepsy.慢性颞叶癫痫的认知预后
Ann Neurol. 2006 Jul;60(1):80-7. doi: 10.1002/ana.20872.
Zotero 插件