C3H/HeJ和BALB/c内源性亲嗜性C型病毒与5号染色体上磷酸葡萄糖变位酶-1的遗传连锁
Genetic linkage of C3H/HeJ and BALB/c endogenous ecotropic C-type viruses to phosphoglucomutase-1 on chromosome 5.
作者信息
Ihle J N, Joseph D R, Domotor J J
出版信息
Science. 1979 Apr 6;204(4388):71-3. doi: 10.1126/science.219476.
PMID:219476
Abstract
The genetic linkage of the endogenous C3H/HeJ C-type ecotropic virus to phosphoglucomutase-1 (0.28, recombinant fraction) on chromosome 5 was established by means of serological assays of backcrossed mice. With a combination of serological techniques and DNA-DNA hybridization the BALB/c endogenous ecotropic virus was shown to be either closely linked or allelic with the C3H/HeJ locus.
摘要
通过对回交小鼠的血清学检测，确定了内源性C3H/HeJ C型亲嗜性病毒与5号染色体上磷酸葡萄糖变位酶-1（重组率为0.28）的遗传连锁关系。结合血清学技术和DNA-DNA杂交分析发现，BALB/c内源性亲嗜性病毒与C3H/HeJ基因座紧密连锁或为等位基因。
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