Psychology Division, Department of Psychiatry, Harbor-UCLA Medical Center, Torrance, CA, USA.
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):324-31. doi: 10.1176/jnp.23.3.jnp324.
The authors investigated the relationship between antiretroviral adherence and HIV-associated verbal memory impairment. HIV-positive participants demonstrated poorer verbal memory than HIV-negative participants. Both good (≥90%) and poor (<90%) adherers displayed encoding deficits as compared with controls, but only poor adherers exhibited retrieval deficits. Encoding deficits primarily accounted for reduced delayed recall in good adherers, but both encoding and retrieval deficits accounted for reduced delayed recall in poor adherers. The retrieval difference between the adherence groups might be explained by a neuroprotective effect of good antiretroviral adherence or preexisting HIV-related retrieval deficits that result in poorer adherence.
作者研究了抗逆转录病毒药物的依从性与 HIV 相关的言语记忆损伤之间的关系。HIV 阳性参与者的言语记忆表现明显差于 HIV 阴性参与者。与对照组相比，依从性好（≥90%）和差（<90%）的患者都表现出了编码缺陷，但只有依从性差的患者表现出了检索缺陷。编码缺陷主要导致了依从性好的患者的延迟回忆能力下降，而依从性差的患者的延迟回忆能力下降则是由于编码和检索缺陷共同导致的。依从性组之间的检索差异可能是由于良好的抗逆转录病毒药物依从性具有神经保护作用，或者由于 HIV 相关的检索缺陷导致依从性较差。
