Dept. of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.
J Neuropsychiatry Clin Neurosci. 2011 Summer;23(3):332-9. doi: 10.1176/jnp.23.3.jnp332.
The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at the category level in order to reduce the number of variables in this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. The authors estimated a tetrachoric correlation matrix among the dichotomous symptom categories and then used exploratory and confirmatory factor analyses to identify a clinically meaningful factor structure for this correlation matrix. Their analysis supported a four-factor solution: obsessions, higher-order repetitive behaviors, lower-order repetitive behaviors, and hoarding. These findings are another step in the effort to identify genetically and biologically distinct groups within this population.
作者在类别水平上对耶鲁-布朗强迫症量表检查表进行了因子分析，以减少该领域的变量数量，并最终确定可能的表型；共纳入 181 名自闭症儿童。作者估计了二分类症状类别之间的四分相关矩阵，然后使用探索性和验证性因子分析来确定该相关矩阵的临床有意义的因子结构。他们的分析支持了一个四因素解决方案：强迫观念、高阶重复行为、低阶重复行为和囤积。这些发现是在努力确定该人群中具有遗传和生物学差异的亚群方面的又一步。
