自闭症谱系障碍中强迫性刻板行为与功能性便秘的关联。
Association of Rigid-Compulsive Behavior with Functional Constipation in Autism Spectrum Disorder.
作者信息
Marler Sarah, Ferguson Bradley J, Lee Evon Batey, Peters Brittany, Williams Kent C, McDonnell Erin, Macklin Eric A, Levitt Pat, Margolis Kara Gross, Beversdorf David Q, Veenstra-VanderWeele Jeremy
机构信息
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
Interdisciplinary Neuroscience Program, The Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, MO, USA.
出版信息
J Autism Dev Disord. 2017 Jun;47(6):1673-1681. doi: 10.1007/s10803-017-3084-6.
Abstract
Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.
摘要
基于自闭症之声自闭症治疗网络的清单数据，我们推测功能性便秘（FC）与自闭症谱系障碍（ASD）儿童的刻板强迫行为有关。我们使用《儿科胃肠道症状问卷-罗马III》评估了108名ASD儿童的FC症状。如我们所推测的，在总体人群中，FC与父母对修订版重复行为量表（RBS-R）中强迫、仪式化和相同性子量表的评分有关。值得注意的是，FC在未服用针对行为或治疗FC的药物的儿童中不太常见。在未服药的儿童中，刻板强迫行为与FC没有显著关联。需要更多的研究来了解这些关联背后的机制。
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1
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2
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J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25.
3
The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder.微生物群-肠-脑轴及其在自闭症谱系障碍中的潜在治疗作用。
Neuroscience. 2016 Jun 2;324:131-9. doi: 10.1016/j.neuroscience.2016.03.013. Epub 2016 Mar 8.
4
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Pediatrics. 2016 Feb;137 Suppl 2(Suppl 2):S105-14. doi: 10.1542/peds.2015-2851I.
5
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Neuroscience. 2016 May 3;321:24-41. doi: 10.1016/j.neuroscience.2015.11.010. Epub 2015 Nov 11.
6
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7
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8
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9
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10
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