Marler Sarah, Ferguson Bradley J, Lee Evon Batey, Peters Brittany, Williams Kent C, McDonnell Erin, Macklin Eric A, Levitt Pat, Margolis Kara Gross, Beversdorf David Q, Veenstra-VanderWeele Jeremy
Department of Psychiatry, Vanderbilt University, Nashville, TN, USA.
Interdisciplinary Neuroscience Program, The Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, Columbia, MO, USA.
J Autism Dev Disord. 2017 Jun;47(6):1673-1681. doi: 10.1007/s10803-017-3084-6.
Based upon checklist data from the Autism Speaks Autism Treatment Network, we hypothesized that functional constipation (FC) would be associated with rigid-compulsive behavior in children with autism spectrum disorder (ASD). We used the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III to assess FC symptoms in 108 children with ASD. As hypothesized, FC was associated with parent ratings on the Repetitive Behavior Scales-Revised (RBS-R) Compulsive, Ritualistic, and Sameness subscales in the overall population. Of note, FC was less common in children who were not taking medications that target behavior or treat FC. In the medication-free children, rigid-compulsive behavior was not significantly associated with FC. More research is needed to understand the mechanisms underlying these associations.
基于自闭症之声自闭症治疗网络的清单数据，我们推测功能性便秘（FC）与自闭症谱系障碍（ASD）儿童的刻板强迫行为有关。我们使用《儿科胃肠道症状问卷-罗马III》评估了108名ASD儿童的FC症状。如我们所推测的，在总体人群中，FC与父母对修订版重复行为量表（RBS-R）中强迫、仪式化和相同性子量表的评分有关。值得注意的是，FC在未服用针对行为或治疗FC的药物的儿童中不太常见。在未服药的儿童中，刻板强迫行为与FC没有显著关联。需要更多的研究来了解这些关联背后的机制。
