Yamabe H
Laboratory of Anatomic Pathology, Kyoto University Hospital.
Rinsho Byori. 1990 Apr;38(4):386-9.
Histopathological features of malignant lymphomas were described and discussed. For the standard classification of malignant lymphomas, the Rye classification for Hodgkin's disease and the International Working Formulation for the non-Hodgkin's lymphoma were recommended. Recent advances in immunology make immunophenotyping of lymphoma cells possible. The usefulness of immunophenotyping in routine paraffin sections was suggested. Some problems of the Working Formulation in classifying T-cell lymphomas were also discussed. A significant difference in the 5-year survival between the different histological grades of Working Formulation and between T and B phenotypes was found in a survey using 604 non-Hodgkin's lymphoma cases of our own. It is concluded that precise histological typing and immunophenotyping of lymphomas are mandatory in the diagnosis, treatment and prediction of the prognosis of patients with malignant lymphomas.
描述并讨论了恶性淋巴瘤的组织病理学特征。对于恶性淋巴瘤的标准分类，推荐采用霍奇金病的赖氏分类法和非霍奇金淋巴瘤的国际工作分类法。免疫学的最新进展使淋巴瘤细胞的免疫表型分析成为可能。有人提出了免疫表型分析在常规石蜡切片中的实用性。还讨论了工作分类法在T细胞淋巴瘤分类中的一些问题。在对我们自己收集的604例非霍奇金淋巴瘤病例进行的一项调查中，发现工作分类法的不同组织学分级以及T和B表型之间的5年生存率存在显著差异。结论是，在恶性淋巴瘤患者的诊断、治疗和预后预测中，淋巴瘤的精确组织学分型和免疫表型分析是必不可少的。
