Departments of Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of Pittsburgh, PA, USA.
Minerva Anestesiol. 2011 Oct;77(10):986-92.
Sepsis is a significant public health problem that affects children and adults alike. Despite some similarities in the approach to pediatric and adult septic shock, there are key differences as it relates to pathophysiology, clinical presentation, and therapeutic approaches. In this review article, we discuss these differences under 4 headings: a) Developmental differences in the hemodynamic response, b) Activated Protein C, c) Thrombocytopenia associated multiple organ failure and d) Hemophagocytic Lymphohistiocytosis (HLH).
败血症是一个严重的公共卫生问题，影响着儿童和成人。尽管儿科和成人感染性休克的治疗方法有些相似，但在病理生理学、临床表现和治疗方法方面存在着关键的差异。在这篇综述文章中，我们将从以下 4 个方面讨论这些差异：a) 血流动力学反应的发育差异；b) 活化蛋白 C；c) 血小板减少相关多器官衰竭；d) 噬血细胞性淋巴组织细胞增多症(HLH)。
