Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
Eur J Immunol. 2011 Sep;41(9):2519-22. doi: 10.1002/eji.201141727.
From many perspectives, cardiovascular diseases and cancers are fundamentally different. On the one hand, atherosclerosis is a disease of lipid accumulation driven by diet and lifestyle, whereas cancer is an attack "from within" driven by mutations. Nevertheless, studies over the past 20 years have forced us to re-evaluate such a view. We are learning that, among other factors, the immune system is indispensable for the development and progression of both diseases. Its components are not only reactive but can also orchestrate both tumor and atherosclerotic lesion growth. In this Viewpoint, we explore how monocytes, which are key constituents of the immune system, forge links between cardiovascular diseases and cancers.
从许多方面来看，心血管疾病和癌症是根本不同的。一方面，动脉粥样硬化是一种由饮食和生活方式驱动的脂质积累疾病，而癌症是一种由突变驱动的“来自内部”的疾病。然而，过去 20 年的研究迫使我们重新评估这种观点。我们了解到，除其他因素外，免疫系统对于这两种疾病的发展和进展都是不可或缺的。它的组成部分不仅具有反应性，而且还可以协调肿瘤和动脉粥样硬化病变的生长。在本观点中，我们探讨了单核细胞作为免疫系统的关键组成部分，如何在心血管疾病和癌症之间建立联系。
