对映选择性有机催化不对称烯丙基烷基化反应。双（苯磺酰基）甲烷与 MBH 碳酸酯加成。
Enantioselective organocatalytic asymmetric allylic alkylation. Bis(phenylsulfonyl)methane addition to MBH carbonates.
机构信息
Department de Química Orgànica, Universitat de Barcelona, Barcelona, Spain.
出版信息
Org Biomol Chem. 2011 Dec 7;9(23):7986-9. doi: 10.1039/c1ob06308a. Epub 2011 Sep 28.
PMID:21952909
Abstract
The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with bis(phenylsulfonyl)methane is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and enantioselectivities.
摘要
本文报道了（手性）金鸡纳生物碱衍生物催化的高度对映选择性不对称烯丙基烷基化 Morita-Baylis-Hillman 碳酸酯与双（苯磺酰基）甲烷的反应。该反应以简单的方式进行，最终得到的烷基化产物产率高，对映选择性好。
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