Department of Neurology, Brain Science and Engineering Institute, Kyungpook National University School of Medicine, Daegu, Korea.
Mov Disord. 2011 Nov;26(13):2364-70. doi: 10.1002/mds.23871. Epub 2011 Sep 23.
Pentraxin 3 is a prototypic long pentraxin. Pentraxin 3 is a soluble recognition receptor that is involved in innate immunity and the inflammatory response. Its expression is induced by proinflammatory signals. The aim of this study was to compare the plasma levels of pentraxin 3 in healthy subjects and patients with neurodegenerative disorders such as mild cognitive impairment, Alzheimer's disease, and Parkinson's disease (PD). Thirty-nine patients with mild cognitive impairment, 75 patients with Alzheimer's disease, 66 patients with PD, and 41 healthy elderly controls were recruited for this study. We performed an extensive battery of neuropsychological tests, including a Mini-Mental Status Examination, clinical dementia rating, and the Unified Parkinson's Disease Rating Scale. A variety of clinical information was collected from the administered semistructured questionnaire. Plasma pentraxin 3 levels were measured using a specific enzyme-linked immunosorbent assay. Plasma pentraxin 3 levels were significantly higher in the PD patients than in the patients with mild cognitive impairment and Alzheimer's disease and in the control subjects. Plasma pentraxin 3 levels in the PD patients were correlated with activities of daily living (r = 0.368; P = .003) and motor function (r = 0.358; P = .004). Plasma pentraxin 3 levels could be a new biochemical marker for PD, and they may be associated with the severity of motor dysfunction and other clinical symptoms in PD patients.
血清淀粉样蛋白 P 成分 3 是典型的长型血清淀粉样蛋白 P 成分。血清淀粉样蛋白 P 成分 3 是一种可溶性识别受体，参与固有免疫和炎症反应。其表达受促炎信号诱导。本研究旨在比较健康受试者和神经退行性疾病患者（如轻度认知障碍、阿尔茨海默病和帕金森病）的血清淀粉样蛋白 P 成分 3 血浆水平。本研究纳入了 39 例轻度认知障碍患者、75 例阿尔茨海默病患者、66 例帕金森病患者和 41 名健康老年对照者。我们进行了一系列神经心理学测试，包括简易精神状态检查、临床痴呆评定量表和统一帕金森病评定量表。从管理的半结构化问卷中收集了各种临床信息。使用特定的酶联免疫吸附试验测量血浆血清淀粉样蛋白 P 成分 3 水平。帕金森病患者的血浆血清淀粉样蛋白 P 成分 3 水平明显高于轻度认知障碍和阿尔茨海默病患者以及对照组。帕金森病患者的血浆血清淀粉样蛋白 P 成分 3 水平与日常生活活动（r = 0.368；P =.003）和运动功能（r = 0.358；P =.004）相关。血浆血清淀粉样蛋白 P 成分 3 水平可能是帕金森病的新生化标志物，可能与帕金森病患者运动功能障碍的严重程度和其他临床症状有关。
