Cátedra de Farmacognosia IQUIMEFA (UBA-CONICET), Facultad de Farmacia y Bioquímica, UBA, Junín 956, CABA, Argentina.
Phytother Res. 2011 Oct;25(10):1466-71. doi: 10.1002/ptr.3444. Epub 2011 Feb 24.
Tilia species have been used in Europe and in America to treat anxiety and also for the treatment of colds, influenza, bronchitis, fever and inflammation. Tilia × viridis is a Tilia species distributed widely in Buenos Aires, Argentina. The flavonoids present in Tilia species have antioxidant properties, acting as reactive oxygen species (ROS) scavengers, principally on hydrogen peroxide (H(2)O(2)) and the superoxide anion (O(2)(·-)), which are involved in many diseases, including cancer. The aim of this study was to determine the phytochemical pattern of the ethanol extract of Tilia × viridis, principally the flavonoid content, and to evaluate the antiproliferative effects on both normal and tumoral cells, and the antioxidant activity in relation to H(2)O(2) modulation. The extract was found to present a selective antiproliferative activity on a lymphoma cell line and this was related to free radical scavenging activity. In addition, one of its main compounds, rutin, showed antioxidant effects related to peroxidase activity. T. × viridis may therefore be a source of antioxidant compounds that contribute to a selective antiproliferative action on tumoral cells, acting by modulation of H(2)O(2) levels.
椴树属植物在欧洲和美洲被用于治疗焦虑症，也用于治疗感冒、流感、支气管炎、发烧和炎症。欧洲椴杂种是一种分布广泛的椴树属植物，分布于阿根廷的布宜诺斯艾利斯。椴树属植物中的类黄酮具有抗氧化特性，作为活性氧 (ROS) 清除剂，主要针对过氧化氢 (H₂O₂) 和超氧阴离子 (O₂(-))，它们涉及许多疾病，包括癌症。本研究旨在确定欧洲椴杂种乙醇提取物的植物化学模式，主要是类黄酮含量，并评估其对正常和肿瘤细胞的抗增殖作用，以及与 H₂O₂ 调节相关的抗氧化活性。研究发现，该提取物对淋巴瘤细胞系具有选择性的抗增殖活性，这与自由基清除活性有关。此外，其主要化合物之一芦丁具有与过氧化物酶活性相关的抗氧化作用。因此，欧洲椴杂种可能是抗氧化化合物的来源，这些化合物通过调节 H₂O₂ 水平对肿瘤细胞具有选择性的抗增殖作用。
