MRI 心肌 T1 映射：Look-Locker 与 MOLLI 序列的比较。
Myocardial T1 mapping with MRI: comparison of look-locker and MOLLI sequences.
机构信息
Radiology and Imaging Sciences - National Institutes of Health Clinical Center, Bethesda, MD, USA; Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Radiology Department, Universidade Federal Fluminense, Niterói, Brazil.
出版信息
J Magn Reson Imaging. 2011 Dec;34(6):1367-73. doi: 10.1002/jmri.22753. Epub 2011 Sep 23.
PURPOSE
To evaluate the relationship between "Look-Locker" (LL) and modified Look-Locker Inversion recovery (MOLLI) approaches for T1 mapping of the myocardium.
MATERIALS AND METHODS
A total of 168 myocardial T1 maps using MOLLI and 165 maps using LL were obtained in human subjects at 1.5 Tesla. The T1 values of the myocardium were calculated before and at five time points after gadolinium administration. All time and heart rate normalizations were done. The T1 values obtained were compared to determine the absolute and bias agreement.
RESULTS
The precontrast global T1 values were similar when measured by the LL and by MOLLI technique (mean, 1004.9 ms ± 120.3 versus 1034.1 ms ± 53.1, respectively, P = 0.26). Postcontrast myocardial T1 time from LL was significantly longer than MOLLI from 5 to 25 min (mean difference, LL - MOLLI was +61.8 ± 46.4 ms, P < 0.001). No significant differences in T1 values were noted between long and short axis measurements for either MOLLI or LL.
CONCLUSION
Postcontrast LL and MOLLI showed very good agreement, although LL values are higher than MOLLI. Precontrast T1 values showed good agreement, however LL has greater limits of agreement. Short and long axis planes can reliably assess T1 values.
目的
评估“Look-Locker”（LL）和改良 Look-Locker 反转恢复（MOLLI）方法在心肌 T1 映射中的关系。
材料和方法
在 1.5T 磁共振扫描仪上，对 168 例人类受试者进行 MOLLI 心肌 T1 映射和 165 例 LL 心肌 T1 映射。在钆剂给药前和给药后 5 个时间点计算心肌的 T1 值。所有时间和心率归一化均完成。比较 T1 值以确定绝对和偏差一致性。
结果
LL 和 MOLLI 技术测量的预对比整体 T1 值相似（平均值，1004.9ms±120.3 与 1034.1ms±53.1，P=0.26）。从 LL 获得的心肌 T1 时间从 5 分钟到 25 分钟比 MOLLI 明显更长（平均差异，LL-MOLLI 为+61.8±46.4ms，P<0.001）。MOLLI 或 LL 对于长轴和短轴测量，T1 值均无明显差异。
结论
尽管 LL 值高于 MOLLI，但对比后 LL 和 MOLLI 显示出非常好的一致性。预对比 T1 值显示出良好的一致性，但 LL 有更大的一致性界限。短轴和长轴平面可以可靠地评估 T1 值。
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