Schwade J G, Houdek P V, Landy H J, Bujnoski J L, Lewin A A, Abitol A A, Serago C F, Pisciotta V J
Department of Radiation Oncology, University of Miami School of Medicine, FL 33101.
Radiology. 1990 Aug;176(2):563-5. doi: 10.1148/radiology.176.2.2195597.
Current techniques of stereotactic, small-field, external-beam irradiation with linear accelerators require treatment with a single fraction or only a few fractions of radiation with large single doses per fraction. Using a radiolucent halo that remained affixed to the cranium with skin-piercing screws, the authors treated 24 patients with a multifraction technique for benign and malignant brain lesions. The objective of this study was to ascertain the feasibility of maintaining the halo in place for a prolonged, multifraction course of treatment, not to assess treatment efficacy. The halo was affixed for multifraction treatments lasting 19-58 days (mean, 38.7 days; median, 40.0 days) and delivered in 16-31 fractions (mean, 24.9 fractions; median, 25.5 fractions). Two of 24 patients experienced superficial skin infection at the site of fixation, but no other significant acute or chronic toxicity attributable to the stereotactic halo was observed. The authors conclude that stereotactic, small-field, precision irradiation can be accomplished with multiple fractions as well as with a single fraction.
当前使用直线加速器进行立体定向、小视野外照射的技术需要单次分割治疗，或者每次分割仅给予少数几次大剂量照射。作者使用一种通过穿皮螺钉固定在颅骨上的射线可透过的头环，采用多分割技术治疗了24例良性和恶性脑病变患者。本研究的目的是确定在长时间多分割治疗过程中保持头环固定在位的可行性，而非评估治疗效果。头环用于持续19 - 58天（平均38.7天；中位数40.0天）的多分割治疗，并分16 - 31次分割给予照射（平均24.9次分割；中位数25.5次分割）。24例患者中有2例在固定部位出现浅表皮肤感染，但未观察到其他归因于立体定向头环的明显急性或慢性毒性反应。作者得出结论，立体定向、小视野、精确照射既可以通过单次分割也可以通过多分割来完成。
