Pozza F, Colombo F, Chierego G, Avanzo R C, Marchetti C, Benedetti A, Casentini L, Danieli D
Department of Radiotherapy, City Hospital, Vicenza, Italy.
Radiology. 1989 May;171(2):565-9. doi: 10.1148/radiology.171.2.2495561.
Fourteen patients with nonoperable low-grade astrocytomas were treated with unconventionally fractionated stereotactic radiation therapy. The target volume was defined with computed tomography (CT) performed under stereotactic conditions. The treatment was carried out with a technique producing multiple noncoplanar arc irradiation, with the center of the target volume placed at the isocenter of the linear accelerator. A total dose of 16-50 Gy was administered in either one fraction or two fractions 8 days apart. The concentration of dose within the target volume allowed reduction of dose absorbed by adjacent critical structures of the intact brain. Patients were followed up for 11-48 months. Twelve of 14 patients had a partial or complete response to treatment, as demonstrated by CT. Stereotactic radiation therapy appears to be effective in the control of small radioresistant cerebral neoplasms, without damaging surrounding healthy tissues.
14例无法手术的低级别星形细胞瘤患者接受了非常规分割立体定向放射治疗。在立体定向条件下通过计算机断层扫描（CT）确定靶体积。采用产生多个非共面弧形照射的技术进行治疗，将靶体积中心置于直线加速器的等中心处。总剂量16 - 50 Gy以单次分割或分两次间隔8天给予。靶体积内的剂量集中使得完整脑内相邻关键结构吸收的剂量得以减少。对患者进行了11 - 48个月的随访。CT显示，14例患者中有12例对治疗有部分或完全反应。立体定向放射治疗似乎对控制小型放射抗拒性脑肿瘤有效，且不会损害周围健康组织。
