一种增强型 DNA 指纹图谱服务，用于调查具有相同 PCR 核糖体分型的潜在艰难梭菌感染病例聚集。
An enhanced DNA fingerprinting service to investigate potential Clostridium difficile infection case clusters sharing the same PCR ribotype.
机构信息
Department of Microbiology, The General Infirmary, Old Medical School, Leeds LS1 3EX, United Kingdom.
出版信息
J Clin Microbiol. 2011 Dec;49(12):4333-7. doi: 10.1128/JCM.05873-11. Epub 2011 Sep 28.
Abstract
Of 53 potential Clostridium difficile infection (CDI) case clusters/outbreaks, affecting 2 to 41 patients in 27 institutions, 19% comprised unrelated isolates and 34% had highly related and distinct isolates as shown by multilocus variable-number tandem-repeat analysis, despite sharing a common ribotype. These findings emphasize the value of enhanced fingerprinting to confirm or refute suspected CDI case clusters.
摘要
在 53 个可能的艰难梭菌感染（CDI）病例群/爆发中，涉及 27 家机构的 2 至 41 名患者，19%的病例由不相关的分离株组成，34%的病例具有高度相关和独特的分离株，这表明尽管存在共同的核糖体分型，但通过多位点可变数串联重复分析显示。这些发现强调了增强指纹图谱以确认或反驳疑似 CDI 病例群的价值。
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