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大鼠离体肠系膜对色胺血管收缩和舒张反应的比较：与酪胺和β-苯乙胺的比较。

Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine.

机构信息

Division of Pharmacology, Welsh School of Pharmacy, Cardiff University, Cardiff, UK.

出版信息

Br J Pharmacol. 2012 Apr;165(7):2191-202. doi: 10.1111/j.1476-5381.2011.01706.x.

DOI:10.1111/j.1476-5381.2011.01706.x
PMID:21958009
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3413856/
Abstract

BACKGROUND AND PURPOSE

Tryptamine increases blood pressure by vasoconstriction, but little is known about its actions on the mesentery, in particular the resistance arteries. Tryptamine interacts with trace amine-associated receptors (TAARs) and because of its structural similarity to 5-HT, it may also interact with 5-HT receptors. Our hypothesis is therefore that the rat mesenteric arterial bed will exhibit vasopressor and vasodepressor responses to tryptamine via both 5-HT and TAARs.

EXPERIMENTAL APPROACH

Tryptamine-evoked responses were assayed from pressure changes of the rat-isolated mesenteric vasculature perfused at constant flow rate in the absence and presence of adrenoceptor and 5-HT receptor antagonists.

KEY RESULTS

Tryptamine caused dose-dependent vasoconstriction of the mesenteric arterial bed as increases in perfusion pressure. These were unaffected by the α(1) -adrenoceptor antagonist, prazosin, but were attenuated by the non-selective α-adrenoceptor antagonist, phentolamine. The 5-HT(2A) receptor antagonists, ketanserin and ritanserin, abolished the tryptamine-induced pressure increases to reveal vasodilator responses in mesenteric beds preconstricted with phenylephrine. These tryptamine-induced vasodilator responses were unaffected by the 5-HT(7) receptor antagonist, SB269970, but were eliminated by the NOS inhibitor, N(ω) -nitro-L-arginine methyl ester (L-NAME). Tyramine and β-phenylethylamine also caused vasodilatation in pre-constricted vasculature, which was also abolished by L-NAME.

CONCLUSIONS AND IMPLICATIONS

Tryptamine causes vasoconstriction of the mesenteric vasculature via 5-HT(2A) receptors, which when inhibited exposed vasorelaxant effects in pre-constricted tissues. The vasodilatation was independent of 5-HT(2A) and 5-HT(7) receptors but like that for tyramine and β-phenylethylamine was due to NO release. Potency orders suggest TAAR involvement in the vasodilatation by these trace amines.

摘要

背景与目的

色胺通过血管收缩增加血压，但对肠系膜的作用知之甚少，特别是阻力动脉。色胺与痕量胺相关受体（TAARs）相互作用，由于其与 5-HT 的结构相似，它也可能与 5-HT 受体相互作用。因此，我们的假设是，大鼠肠系膜动脉床将通过 5-HT 和 TAARs 对色胺表现出升压和降压反应。

实验方法

在恒定流量下灌注大鼠分离肠系膜血管时，从肠系膜血管的压力变化中测定色胺诱发的反应，在不存在和存在肾上腺素能受体和 5-HT 受体拮抗剂的情况下。

主要结果

色胺引起肠系膜动脉床的剂量依赖性血管收缩，导致灌注压升高。这些变化不受 α(1)-肾上腺素能受体拮抗剂哌唑嗪的影响，但被非选择性 α-肾上腺素能受体拮抗剂酚妥拉明减弱。5-HT(2A)受体拮抗剂酮色林和利坦色林消除了色胺引起的压力升高，揭示了预先用苯肾上腺素预收缩的肠系膜床上的血管扩张反应。这些色胺诱导的血管扩张反应不受 5-HT(7)受体拮抗剂 SB269970 的影响，但被一氧化氮合酶抑制剂 N(ω)-硝基-L-精氨酸甲酯 (L-NAME) 消除。酪胺和β-苯乙胺也引起预先收缩的血管扩张，这种扩张也被 L-NAME 消除。

结论和意义

色胺通过 5-HT(2A)受体引起肠系膜血管收缩，当抑制这些受体时，在预先收缩的组织中暴露血管舒张作用。血管舒张与 5-HT(2A)和 5-HT(7)受体无关，但与酪胺和β-苯乙胺相似，是由于一氧化氮释放所致。效力顺序表明 TAAR 参与这些痕量胺的血管舒张作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/40f885414608/bph0165-2191-f9.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/2d555a3ec4ef/bph0165-2191-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/40f885414608/bph0165-2191-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/c0385310bcf5/bph0165-2191-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/10644eaed2a2/bph0165-2191-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/8dfe37098193/bph0165-2191-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b3e/3413856/c2c9950e9c4f/bph0165-2191-f7.jpg
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本文引用的文献

1
Guide to Receptors and Channels (GRAC), 5th edition.《受体和离子通道手册》（GRAC）第 5 版。
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2
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Naunyn Schmiedebergs Arch Pharmacol. 2010 Oct;382(4):385-98. doi: 10.1007/s00210-010-0554-1. Epub 2010 Sep 1.
3
The vascular effects of trace amines and amphetamines.
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4
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Adv Exp Med Biol. 2022;1383:307-318. doi: 10.1007/978-3-031-05843-1_28.
5
Migraine signaling pathways: amino acid metabolites that regulate migraine and predispose migraineurs to headache.偏头痛信号通路：调节偏头痛和使偏头痛患者易发生头痛的氨基酸代谢物。
Mol Cell Biochem. 2022 Sep;477(9):2269-2296. doi: 10.1007/s11010-022-04438-9. Epub 2022 Apr 28.
6
Metabolite G-Protein Coupled Receptors in Cardio-Metabolic Diseases.代谢物 G 蛋白偶联受体在心脏代谢疾病中的作用。
Cells. 2021 Nov 29;10(12):3347. doi: 10.3390/cells10123347.
7
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8
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Sci Rep. 2019 Jul 29;9(1):10925. doi: 10.1038/s41598-019-46627-5.
10
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Neurol Sci. 2019 May;40(Suppl 1):39-44. doi: 10.1007/s10072-019-03768-9.
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Pharmacol Ther. 2010 Mar;125(3):363-75. doi: 10.1016/j.pharmthera.2009.11.005. Epub 2009 Dec 4.
4
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Cell Mol Life Sci. 2009 Aug;66(16):2743-57. doi: 10.1007/s00018-009-0076-5. Epub 2009 Jul 9.
5
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Mol Pharmacol. 2009 Aug;76(2):229-35. doi: 10.1124/mol.109.055970. Epub 2009 Apr 23.
6
Effects of dietary amines on the gut and its vasculature.膳食胺对肠道及其血管系统的影响。
Br J Nutr. 2009 Jun;101(11):1645-52. doi: 10.1017/S0007114508123431. Epub 2008 Nov 19.
7
Dietary trace amine-dependent vasoconstriction in porcine coronary artery.猪冠状动脉中膳食痕量胺依赖性血管收缩作用
Br J Pharmacol. 2008 Oct;155(4):525-34. doi: 10.1038/bjp.2008.286. Epub 2008 Jul 7.
8
Cardiac effects of trace amines: pharmacological characterization of trace amine-associated receptors.痕量胺的心脏效应：痕量胺相关受体的药理学特性
Eur J Pharmacol. 2008 Jun 10;587(1-3):231-6. doi: 10.1016/j.ejphar.2008.03.055. Epub 2008 Apr 7.
9
Trace amine-associated receptor 1-Family archetype or iconoclast?痕量胺相关受体1——家族原型还是叛逆者？
Pharmacol Ther. 2007 Dec;116(3):355-90. doi: 10.1016/j.pharmthera.2007.06.007. Epub 2007 Jul 17.
10
Trace amine-associated receptors and their ligands.痕量胺相关受体及其配体。
Br J Pharmacol. 2006 Dec;149(8):967-78. doi: 10.1038/sj.bjp.0706948. Epub 2006 Nov 6.