Division of Metabolism, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
Urology. 2011 Nov;78(5):1040-5. doi: 10.1016/j.urology.2011.05.017. Epub 2011 Sep 28.
To evaluate overactive bladder (OAB, dry and wet) and the associated risk factors of OAB wet (with incontinence) in type 2 diabetes.
A self-administered questionnaire containing the OAB symptom score (OABSS, 0-15, with higher numbers indicating an increasing severity of symptoms) was obtained from subjects with type 2 diabetes at a dedicated diabetic center. The association of age, sex, duration of diabetes, body mass index, waist circumference, glycated hemoglobin level, high-sensitive C-reactive protein level, and diabetes-associated complications to the risk of OAB and OAB wet was evaluated.
Of 1359 consecutive subjects, 22.5% reported having OAB, with 11.7% reporting OAB dry and 10.8% OAB wet. The difference in symptom severity was statistically significant among those without OAB and those with OAB dry and OAB wet (OABSS 2.5 ± 1.4, 5.9 ± 1.6, and 8.9 ± 2.6, respectively). The prevalence of OAB and OAB wet was 2.4-fold and 4.2-fold greater, respectively, in patients with a diabetes duration >10 years and age >50 years. Age and male sex and age and waist circumference were independent risk factors for OAB and OAB wet, respectively, after multivariate analysis. Glycated hemoglobin and high-sensitivity C-reactive protein levels were similar between patients with diabetes patients with and without OAB.
In the dedicated diabetic center in which all patients were screened, 22.5% had OAB, and 48.0% of those with OAB had incontinence. These findings can help guide the collaboration between urologists and diabetologists to work toward developing screening for, and early treatment of, urologic complications in higher risk patients.
评估 2 型糖尿病患者中膀胱过度活动症（OAB，干、湿两种）及其相关湿型 OAB（伴失禁）的风险因素。
在专门的糖尿病中心，向 2 型糖尿病患者发放一份包含膀胱过度活动症症状评分（OABSS，0-15 分，分数越高表示症状越严重）的自填式问卷，评估年龄、性别、糖尿病病程、体重指数、腰围、糖化血红蛋白水平、高敏 C 反应蛋白水平以及糖尿病相关并发症与 OAB 和 OAB 湿型的风险之间的关联。
在 1359 例连续患者中，22.5%报告患有 OAB，11.7%报告患有 OAB 干型，10.8%报告患有 OAB 湿型。无 OAB 与 OAB 干型和 OAB 湿型患者之间的症状严重程度差异具有统计学意义（OABSS 分别为 2.5±1.4、5.9±1.6 和 8.9±2.6）。病程>10 年和年龄>50 岁的患者中，OAB 和 OAB 湿型的患病率分别增加了 2.4 倍和 4.2 倍。多变量分析后，年龄和男性、年龄和腰围分别是 OAB 和 OAB 湿型的独立危险因素。糖化血红蛋白和高敏 C 反应蛋白水平在伴有或不伴有 OAB 的糖尿病患者之间相似。
在进行了全面筛查的专门糖尿病中心中，22.5%的患者患有 OAB，其中 48.0%的患者存在失禁。这些发现有助于指导泌尿科医生和糖尿病医生之间的合作，针对高危患者开展泌尿系统并发症的筛查和早期治疗。
