Department of Chemistry, University of Basel, Spitalstrasse 51, CH-4056 Basel, Switzerland.
Chem Commun (Camb). 2011 Nov 28;47(44):12065-7. doi: 10.1039/c1cc15004a. Epub 2011 Sep 30.
Incorporation of a biotinylated Hoveyda-Grubbs catalyst within (strept)avidin affords artificial metalloenzymes for the ring-closing metathesis of N-tosyl diallylamine in aqueous solution. Optimization of the performance can be achieved either by chemical or genetic means.
将生物素化的 Hoveyda-Grubbs 催化剂结合到（链霉）亲和素中，为 N-对甲苯磺酰基烯丙胺在水溶液中环 closing metathesis 提供了人工金属酶。可以通过化学或遗传手段优化性能。
