Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Magn Reson Med Sci. 2011;10(3):193-9. doi: 10.2463/mrms.10.193.
Fluid-attenuated inversion recovery (FLAIR) has been reported more sensitive than T(1)-weighted images in detecting low concentration gadolinium-based contrast media (GBCM) in fluid, and heavily T(2)-weighted (hT(2)W) 3-dimensional (3D) FLAIR has recently been reported even more sensitive than conventional 3D FLAIR. We investigated whether high signal of the anterior eye segment (AES) and subarachnoid space (SAS) in various locations as well as cerebrospinal fluid (CSF) in cisterns and ventricles can be detected on hT(2)W 3D FLAIR images obtained 4 hours after intravenous administration of GBCM in subjects without eye and SAS diseases.
Ten patients suspected of having Ménière's disease underwent hT(2)W 3D FLAIR 4 hours after intravenous administration of single-dose GBCM to evaluate endolymphatic hydrops. We evaluated signal intensity of AES, SAS surrounding the optic nerve, SAS in Meckel's cave, CSF in the internal auditory canal, CSF in the prepontine cistern, CSF in the lateral and fourth ventricles, and lymph fluid in the cochlea by comparison with non-contrast images obtained in a separate group of 5 patients. The signal intensity of each structure was normalized by that of the pontine parenchyma.
We observed no signal difference in images of the pontine parenchyma obtained before and after enhancement. Significant signal difference was seen in all structures except the lateral and fourth ventricles.
Four hours after intravenous injection, GBCM can be detected by hT(2)W 3D FLAIR in various fluid-containing spaces, such as the AES and various SAS and CSF spaces.
与 T1 加权图像相比，液体衰减反转恢复（FLAIR）已被报道在检测液体中低浓度钆基对比剂（GBCM）方面更敏感，而最近报道的重度 T2 加权（hT2W）三维（3D）FLAIR 甚至比常规 3D FLAIR 更敏感。我们研究了在没有眼部和 SAS 疾病的受试者中，静脉注射 GBCM 4 小时后，是否可以在 hT2W 3D FLAIR 图像上检测到前眼前节（AES）和蛛网膜下腔（SAS）各个部位以及脑池和脑室中的高信号。
10 例疑似梅尼埃病的患者在静脉注射单剂量 GBCM 后 4 小时行 hT2W 3D FLAIR 检查，以评估内淋巴积水。我们通过与 5 例单独一组患者的非对比图像进行比较，评估了 AES、视神经周围的 SAS、Meckel 氏腔中的 SAS、内听道中的 CSF、桥前池中的 CSF、外侧和第四脑室中的 CSF 以及耳蜗中的淋巴液的信号强度。各结构的信号强度通过桥脑实质的信号强度进行归一化。
我们观察到增强前后桥脑实质图像无信号差异。除外侧和第四脑室外，所有结构均可见明显信号差异。
静脉注射后 4 小时，hT2W 3D FLAIR 可检测到 AES 及各种 SAS 和 CSF 空间等各种含液空间中的 GBCM。
