核仁蛋白 Spindlin1 识别 H3K4 甲基化并刺激 rRNA 基因的表达。
Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.
机构信息
Chromatin Lab, National Institute of Biological Sciences, 7 Science Park Road, Zhong Guan Cun Life Science Park, Beijing 102206, China.
出版信息
EMBO Rep. 2011 Oct 28;12(11):1160-6. doi: 10.1038/embor.2011.184.
Abstract
The tandem Tudor-like domain-containing protein Spindlin1 has been reported to be a meiotic spindle-associated protein. Here we report that Spindlin1 is not associated with the spindle in mouse embryonic fibroblast cells during mitotic divisions. In interphase cells, Spindlin1 specifically localizes to the nucleoli. Moreover, Spindlin1 is a histone methylation effector protein that specifically recognizes H3K4 methylation. Finally, Spindlin1 localizes to the active ribosomal DNA (rDNA) repeats, and Spindlin1 facilitates the expression of rRNA genes.
摘要
串联 Tudor 样结构域蛋白 Spindlin1 已被报道为一种减数分裂纺锤体相关蛋白。在这里，我们报告说，在有丝分裂分裂过程中，Spindlin1 与小鼠胚胎成纤维细胞中的纺锤体没有关联。在间期细胞中，Spindlin1 特异性定位于核仁。此外，Spindlin1 是一种组蛋白甲基化效应蛋白，特异性识别 H3K4 甲基化。最后，Spindlin1 定位于活性核糖体 DNA（rDNA）重复序列，并且 Spindlin1 促进 rRNA 基因的表达。
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