萘基角蛋白加合物作为喷气燃料暴露生物标志物的实用性。
The utility of naphthyl-keratin adducts as biomarkers for jet-fuel exposure.
机构信息
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina at Chapel Hill, USA.
出版信息
Biomarkers. 2011 Nov;16(7):590-9. doi: 10.3109/1354750X.2011.611598. Epub 2011 Sep 30.
We investigated the association between biomarkers of dermal exposure, naphthyl-keratin adducts (NKA), and urine naphthalene biomarker levels in 105 workers routinely exposed to jet-fuel. A moderate correlation was observed between NKA and urine naphthalene levels (p = 0.061). The NKA, post-exposure breath naphthalene, and male gender were associated with an increase, while CYP2E1*6 DD and GSTT1-plus (++/+-) genotypes were associated with a decrease in urine naphthalene level (p < 0.0001). The NKA show great promise as biomarkers for dermal exposure to naphthalene. Further studies are warranted to characterize the relationship between NKA, other exposure biomarkers, and/or biomarkers of biological effects due to naphthalene and/or PAH exposure.
我们研究了 105 名常规接触喷气燃料的工人的皮肤暴露生物标志物、萘基角蛋白加合物（NKA）和尿萘生物标志物水平之间的关联。NKA 与尿萘水平之间存在中度相关性（p=0.061）。NKA、暴露后呼吸萘、男性性别与尿萘水平升高相关，而 CYP2E1*6 DD 和 GSTT1-（++/+-）基因型与尿萘水平降低相关（p<0.0001）。NKA 作为皮肤接触萘的生物标志物具有很大的潜力。需要进一步的研究来描述 NKA 与其他暴露生物标志物和/或由于萘和/或 PAH 暴露导致的生物效应标志物之间的关系。
Zotero 插件