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Interim methadone treatment compared to standard methadone treatment: 4-month findings.美沙酮临时治疗与标准美沙酮治疗比较:4 个月的结果。
J Subst Abuse Treat. 2011 Jul;41(1):21-9. doi: 10.1016/j.jsat.2011.01.008. Epub 2011 Feb 24.
2
Buprenorphine implants for treatment of opioid dependence: a randomized controlled trial.丁丙诺啡透皮贴剂治疗阿片类药物依赖的随机对照试验
JAMA. 2010 Oct 13;304(14):1576-83. doi: 10.1001/jama.2010.1427.
3
Incarceration and opioid withdrawal: the experiences of methadone patients and out-of-treatment heroin users.监禁与阿片类药物戒断:美沙酮治疗患者及戒毒海洛因使用者的经历
J Psychoactive Drugs. 2009 Jun;41(2):145-52. doi: 10.1080/02791072.2009.10399907.
4
Why don't out-of-treatment individuals enter methadone treatment programmes?为什么脱毒治疗的个体不进入美沙酮维持治疗项目?
Int J Drug Policy. 2010 Jan;21(1):36-42. doi: 10.1016/j.drugpo.2008.07.004. Epub 2008 Sep 20.
5
Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence.丁丙诺啡维持治疗与安慰剂或美沙酮维持治疗用于阿片类物质依赖的比较
Cochrane Database Syst Rev. 2008 Apr 16(2):CD002207. doi: 10.1002/14651858.CD002207.pub3.
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Sustained-release naltrexone: novel treatment for opioid dependence.长效纳曲酮:阿片类药物依赖的新型治疗方法。
Expert Opin Investig Drugs. 2007 Aug;16(8):1285-94. doi: 10.1517/13543784.16.8.1285.
7
A randomized controlled trial of interim methadone maintenance.美沙酮维持治疗中期的一项随机对照试验。
Arch Gen Psychiatry. 2006 Jan;63(1):102-9. doi: 10.1001/archpsyc.63.1.102.
8
French field experience with buprenorphine.法国丁丙诺啡的实地经验。
Am J Addict. 2004;13 Suppl 1:S17-28. doi: 10.1080/10550490490440780.
9
From morphine clinics to buprenorphine: regulating opioid agonist treatment of addiction in the United States.从吗啡诊所到丁丙诺啡:美国对阿片类激动剂成瘾治疗的监管
Drug Alcohol Depend. 2003 May 21;70(2 Suppl):S3-11. doi: 10.1016/s0376-8716(03)00055-3.
10
Beliefs about methadone in an inner-city methadone clinic.关于市中心美沙酮诊所中美沙酮的看法。
J Urban Health. 2002 Dec;79(4):571-8. doi: 10.1093/jurban/79.4.571.

非裔美国患者在公共部门寻求治疗:丁丙诺啡与美沙酮患者的特征比较。

African American patients seeking treatment in the public sector: characteristics of buprenorphine vs. methadone patients.

机构信息

Friends Research Institute, Inc., 1040 Park Avenue, Baltimore, MD 21201, USA.

出版信息

Drug Alcohol Depend. 2012 Apr 1;122(1-2):55-60. doi: 10.1016/j.drugalcdep.2011.09.009. Epub 2011 Sep 29.

DOI:10.1016/j.drugalcdep.2011.09.009
PMID:21962726
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3251709/
Abstract

BACKGROUND

To expand its public-sector treatment capacity, Baltimore City made buprenorphine treatment accessible to low-income, largely African American residents. This study compares the characteristics of patients entering methadone treatment vs. buprenorphine treatment to determine whether BT was attracting different types of patients.

METHODS

Participants consisted of two samples of adult heroin-dependent African Americans. The first sample was newly admitted to a health center or a mental health center providing buprenorphine (N=200), and the second sample was newly admitted to one of two hospital-based methadone programs (N=178). The Addiction Severity Index (ASI) and the Friends Supplemental Questionnaire were administered at treatment entry and data were analyzed with logistic regression.

RESULTS

BT participants were more likely to be female (p=.017) and less likely to inject (p=.001). Participants with only prior buprenorphine treatment experience were nearly five time more likely to enter buprenorphine than methadone treatment (p<.001). Those with experience with both treatments were more than twice as likely to enter BT (OR=2.7, 95% CI=1.11-6.62; p=.028). In the 30 days prior to treatment entry, BT participants reported more days of medical problems (p=.002) and depression (p=.044), and were more likely to endorse a lifetime history of depression (p<.001).

CONCLUSION

Methadone and buprenorphine treatment provided in the public sector may attract different patient subpopulations. Providing buprenorphine treatment through drug treatment programs co-located with a health and mental health center may have accounted for their higher rates of medical and psychiatric problems and appears to be useful in attracting a diverse group of patients into public-sector funded treatment.

摘要

背景

为了扩大公共部门的治疗能力,巴尔的摩市让低收入、以非裔美国人为主的居民能够获得丁丙诺啡治疗。本研究比较了进入美沙酮治疗和丁丙诺啡治疗的患者特征,以确定 BT 是否吸引了不同类型的患者。

方法

参与者由两组成年非裔美国海洛因依赖者组成。第一组是新进入健康中心或提供丁丙诺啡的心理健康中心的患者(N=200),第二组是新进入两家医院美沙酮项目的患者(N=178)。在治疗开始时,对参与者进行成瘾严重程度指数(ASI)和朋友补充问卷的评估,并使用逻辑回归分析数据。

结果

BT 组的参与者更有可能是女性(p=.017),不太可能注射(p=.001)。只有丁丙诺啡治疗经验的参与者进入丁丙诺啡治疗的可能性是美沙酮治疗的近五倍(p<.001)。有两种治疗经验的参与者进入 BT 的可能性是美沙酮治疗的两倍多(OR=2.7,95% CI=1.11-6.62;p=.028)。在治疗开始前的 30 天内,BT 组报告的医疗问题(p=.002)和抑郁(p=.044)天数更多,并且更有可能有过抑郁的终生病史(p<.001)。

结论

公共部门提供的美沙酮和丁丙诺啡治疗可能吸引不同的患者亚群。在与健康和心理健康中心同地设立的药物治疗项目中提供丁丙诺啡治疗,可能导致他们出现更高的医疗和精神健康问题,并且似乎有助于吸引更多不同背景的患者进入公共部门资助的治疗。