胸腺中的决策检查点。
Decision checkpoints in the thymus.
机构信息
Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Immunol. 2010 Aug;11(8):666-73. doi: 10.1038/ni.1887. Epub 2010 Jul 20.
Abstract
The development of T cells in the thymus involves several differentiation and proliferation events, during which hematopoietic precursors give rise to T cells ready to respond to antigen stimulation and undergo effector differentiation. This review addresses signaling and transcriptional checkpoints that control the intrathymic journey of T cell precursors. We focus on the divergence of alphabeta and gammadelta lineage cells and the elaboration of the alphabeta T cell repertoire, with special emphasis on the emergence of transcriptional programs that direct lineage decisions.
摘要
胸腺中 T 细胞的发育涉及几个分化和增殖事件，在此期间，造血前体产生准备对抗原刺激做出反应并进行效应分化的 T 细胞。本综述讨论了控制 T 细胞前体胸腺内途径的信号转导和转录检查点。我们专注于 alphabeta 和 gammadelta 谱系细胞的分歧以及 alphabeta T 细胞库的阐述，特别强调指导谱系决定的转录程序的出现。
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