Laboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Curr Opin Immunol. 2012 Apr;24(2):139-45. doi: 10.1016/j.coi.2012.02.002. Epub 2012 Mar 2.
The proper choice of the CD4-helper or CD8-cytotoxic lineages by developing T cells is crucial for the generation of an antigen-responsive and functionally fit T cell repertoire. Here we present a brief overview of the transcriptional control of this process, with emphasis on two issues. The study of Cd4 expression, that had previously generated important paradigms for transcriptional regulation in eukaryotic cells, now brings new twists to the concept of 'epigenetic memory'. And connections are emerging between transcriptional regulators critical for commitment to either lineage. The present review attempts to integrate these findings and discusses the still elusive mechanisms that match CD4-CD8 lineage differentiation to MHC specificity.
发展中的 T 细胞对 CD4-辅助或 CD8-细胞毒性谱系的正确选择对于产生抗原反应性和功能健全的 T 细胞库至关重要。在这里，我们简要概述了这一过程的转录控制，重点介绍了两个问题。对 Cd4 表达的研究以前为真核细胞的转录调控提供了重要的范例，现在为“表观遗传记忆”的概念带来了新的变化。而且，对于决定向任一谱系分化至关重要的转录调节剂之间也出现了联系。本综述试图整合这些发现，并讨论仍难以捉摸的机制，将 CD4-CD8 谱系分化与 MHC 特异性相匹配。
