Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, Seoul 137-701, Republic of Korea.
Diabetes Res Clin Pract. 2012 Jan;95(1):42-7. doi: 10.1016/j.diabres.2011.09.006. Epub 2011 Sep 29.
To evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and arterial stiffness in patients with type 2 diabetes.
Serum 25(OH)D was measured in a cross-sectional sample of 131 men and 174 women aged 30 years and over in Korea. Arterial stiffness was assessed by pulse wave velocity (PWV) obtained with a VP-2000 pulse wave unit. Fasting plasma glucose, insulin, lipid profile, HbA1c, calcium, phosphorous, and HS-CRP were measured.
The prevalence of vitamin D deficiency was high (85.9%). Those with lower vitamin D levels had increased PWV. Using multivariate regression analysis, low 25(OH)D concentrations independently predicted PWV (p<0.001) in people with type 2 diabetes after adjustment for other risk factors such as age, smoking, hypertension, HS-CRP, diabetes duration, hypertension duration, HbA1c, and BMI.
Vitamin D deficiency is common in type 2 diabetes, and a low 25(OH)D level is significantly associated with increased arterial stiffness in these patients. Vitamin D may influence the development of cardiovascular disease. Clinical intervention studies are needed to clarify whether treatment with vitamin D decreases the risk of cardiovascular disease in patients with type 2 diabetes.
评估 2 型糖尿病患者血清 25-羟维生素 D [25(OH)D]与动脉僵硬度的关系。
在韩国，对年龄在 30 岁及以上的 131 名男性和 174 名女性进行了横断面样本的血清 25(OH)D 测量。使用 VP-2000 脉搏波单元评估动脉僵硬度。测量空腹血糖、胰岛素、血脂谱、HbA1c、钙、磷和高敏 C 反应蛋白。
维生素 D 缺乏的患病率很高（85.9%）。维生素 D 水平较低的患者 PWV 增加。使用多变量回归分析，在调整了年龄、吸烟、高血压、高敏 C 反应蛋白、糖尿病病程、高血压病程、HbA1c 和 BMI 等其他危险因素后，低 25(OH)D 浓度独立预测了 2 型糖尿病患者的 PWV（p<0.001）。
2 型糖尿病患者中维生素 D 缺乏很常见，低 25(OH)D 水平与这些患者动脉僵硬度增加显著相关。维生素 D 可能影响心血管疾病的发生。需要进行临床干预研究，以明确维生素 D 治疗是否降低 2 型糖尿病患者心血管疾病的风险。
