Tabata Hiromitsu, Shimizu Naoki, Wada Yoshiro, Miura Kenichiro, Kawano Kenji
Department of Integrative Brain Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
J Vis. 2010 Jan 29;10(1):13.1-17. doi: 10.1167/10.1.13.
To study the initial part of the mouse optokinetic response, OKR (approximately 500 ms from the onset of visual stimulus motion), we recorded the ocular response to a vertical sinusoidal grating moving at a constant velocity. We found that the magnitude of the response monotonically increased as the stimulus contrast increased. The response showed a narrow band-pass property for the spatiotemporal frequency, with the largest sustained response observed at 0.125 cycle/deg and 1.5 Hz. We also found that temporal frequencies higher than 1.5 Hz elicited transient increase in the eye velocity, but weak or no sustained eye movements. Thus the initial OKR in mice is characterized by the spatiotemporal frequency of the visual stimuli. Our results suggest that the initial OKR contains two components: a transient that diminishes within approximately 200 ms, and a tonic that is maintained for more than 400 ms, and that the initial part of the OKR in mice is an appropriate measurement parameter for studies of the visual and motor systems, like ocular following response (OFR) in primates.
为了研究小鼠视动反应（OKR）的初始部分（从视觉刺激运动开始约500毫秒），我们记录了对以恒定速度移动的垂直正弦光栅的眼部反应。我们发现，随着刺激对比度的增加，反应幅度单调增加。该反应对时空频率表现出窄带通特性，在0.125周期/度和1.5赫兹时观察到最大的持续反应。我们还发现，高于1.5赫兹的时间频率会引起眼速度的短暂增加，但持续的眼球运动微弱或没有。因此，小鼠的初始OKR以视觉刺激的时空频率为特征。我们的结果表明，初始OKR包含两个成分：一个在约200毫秒内减弱的瞬态成分，和一个持续超过400毫秒的紧张性成分，并且小鼠OKR的初始部分是用于研究视觉和运动系统的合适测量参数，类似于灵长类动物的眼跟踪反应（OFR）。
