在强制性 SET 政策中冷冻保存的贡献：对学术 IVF 中心 5 年法律应用的分析。
Contribution of cryopreservation in a mandatory SET policy: analysis of 5 years of application of law in an academic IVF center.
机构信息
Fertility Clinic, department obstetrics/gynecology, hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, 1070, Brussels, Belgium.
出版信息
J Assist Reprod Genet. 2011 Nov;28(11):1059-66. doi: 10.1007/s10815-011-9642-5. Epub 2011 Oct 1.
OBJECTIVE
To analyse treatment outcomes after SET law enforcement and to evaluate the contribution of cryopreservation in a SET policy.
MATERIAL
Embryo transfer cycles performed after the law enforcement (SET period) was retrospectively compared to the cycles performed before the law enforcement (DET period).
RESULTS
Pregnancy and delivery rates after fresh transfer of SET and DET periods were comparable (31.7% versus 33.3% and 24.5% versus 26.2%, respectively, NS). Overall twin delivery rate is significantly decreased after the law enforcement (11.3% versus 22.4%, p < 0.001) but not in patients aged 36 to 39 years (20.3% versus 24%, NS). Frozen-thawed embryo cycles allowed similar cumulative pregnancy rate (30.6%, NS). Taking into account all frozen embryos still to be transferred, SET period offers a better overall pregnancy rate than the DET period (36.1% versus 32.3%, p < 0.01).
CONCLUSIONS
The Belgian law allowed a dramatic reduction of twin deliveries especially for patients under 39 years. Cryopreservation maintains a similar cumulative pregnancy rate.
目的
分析 SET 法实施后的治疗结果，并评估冷冻保存在 SET 政策中的作用。
材料
对实施 SET 法（SET 期）后的胚胎移植周期进行回顾性比较，与实施 SET 法前（DET 期）的周期进行比较。
结果
新鲜移植 SET 和 DET 周期后的妊娠和分娩率相当（分别为 31.7%对 33.3%和 24.5%对 26.2%，无统计学意义）。实施 SET 法后，总体双胞胎分娩率显著降低（11.3%对 22.4%，p<0.001），但 36-39 岁患者中无统计学意义（20.3%对 24%，无统计学意义）。冷冻胚胎移植周期允许类似的累积妊娠率（30.6%，无统计学意义）。考虑到所有待转移的冷冻胚胎，SET 期的总妊娠率优于 DET 期（36.1%对 32.3%，p<0.01）。
结论
比利时法律允许大幅度减少双胞胎分娩，尤其是对于 39 岁以下的患者。冷冻保存维持了类似的累积妊娠率。
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