Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Am J Respir Crit Care Med. 2011 Oct 1;184(7):848-56. doi: 10.1164/rccm.201104-0634WS.
The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) held a workshop to develop recommendations on topics, methodologies, and resources for comparative effectiveness research (CER) that will guide clinical decision making about available treatment options for lung diseases and sleep disorders. A multidisciplinary group of experts with experience in efficacy, effectiveness, implementation, and economic research identified (a) what types of studies the domain of CER in lung diseases and sleep disorders should include, (b) the criteria and process for setting priorities, and (c) current resources for and barriers to CER in lung diseases. Key recommendations were to (1) increase efforts to engage stakeholders in developing CER questions and study designs; (2) invest in further development of databases and other infrastructure, including efficient methods for data sharing; (3) make full use of a broad range of study designs; (4) increase the appropriate use of observational designs and the support of methodologic research; (5) ensure that committees that review CER grant applications include persons with appropriate perspective and expertise; and (6) further develop the workforce for CER by supporting training opportunities that focus on the methodologic and practical skills needed.
美国国立心肺血液研究所（NHLBI）的肺部疾病分部举行了一次研讨会，旨在就比较疗效研究（CER）的主题、方法和资源制定建议，以指导有关肺部疾病和睡眠障碍可用治疗方案的临床决策。一个在疗效、效果、实施和经济研究方面具有经验的多学科专家小组确定了：（a）CER 在肺部疾病和睡眠障碍领域应包括哪些类型的研究；（b）确定优先事项的标准和程序；（c）CER 在肺部疾病方面的当前资源和障碍。关键建议包括：（1）加大力度让利益攸关方参与制定 CER 问题和研究设计；（2）投资进一步开发数据库和其他基础设施，包括数据共享的有效方法；（3）充分利用广泛的研究设计；（4）增加对观察性设计的适当使用和对方法学研究的支持；（5）确保审查 CER 拨款申请的委员会包括具有适当观点和专业知识的人员；（6）通过支持专注于所需方法学和实践技能的培训机会，进一步发展 CER 人员队伍。
