Stanford University School of Medicine, Stanford, California 94305-5405, USA.
J Am Coll Cardiol. 2012 Aug 14;60(7):569-80. doi: 10.1016/j.jacc.2011.12.057. Epub 2012 Jul 11.
Comparative effectiveness research (CER) aims to provide decision makers with the evidence needed to evaluate the benefits and harms of alternative clinical management strategies. CER has become a national priority, with considerable new research funding allocated. Cardiovascular disease is a priority area for CER. This workshop report provides an overview of CER methods, with an emphasis on practical clinical trials and observational treatment comparisons. The report also details recommendations to the National Heart, Lung, and Blood Institute for a new framework for evidence development to foster cardiovascular CER, and specific studies to address 8 clinical issues identified by the Institute of Medicine as high priorities for cardiovascular CER.
比较效果研究（CER）旨在为决策者提供评估替代临床管理策略的益处和危害所需的证据。CER 已成为国家优先事项，分配了大量新的研究资金。心血管疾病是 CER 的重点领域。本研讨会报告提供了 CER 方法的概述，重点介绍了实用的临床试验和观察性治疗比较。该报告还详细介绍了向美国国立心肺血液研究所（National Heart，Lung，and Blood Institute）提出的建议，以制定新的证据开发框架，促进心血管 CER，并开展具体研究，以解决医学研究所确定的 8 个临床问题，这些问题是心血管 CER 的重点。
