一种八硫代糖基化锌（II）酞菁的合成与光物理性质
Synthesis and photophysics of an octathioglycosylated zinc(II) phthalocyanine.
作者信息
Aggarwal Amit, Singh Sunaina, Zhang Yazhou, Anthes Mariah, Samaroo Diana, Gao Ruomei, Drain Charles Michael
机构信息
Department of Chemistry and Biochemistry, Hunter College of the City University of New York, 695 Park Avenue, New York, New York 10065, USA.
出版信息
Tetrahedron Lett. 2011 Oct 19;52(42):5456-5459. doi: 10.1016/j.tetlet.2011.08.028.
Abstract
A water soluble zinc(II) phthalocyanine symmetrically appended with eight thioglucose units was synthesized from commercially available hexadecafluorophthalocyaninatozinc(II) by controlled nucleophilic substitution of the peripheral fluoro groups. The photophysical properties and cancer cell uptake studies of this nonhydrolyzable thioglycosylated phthalocyanine are reported. The new compound has amphiphilic character, is chemically stable, and can potentially be used as a photosensitizer in photodynamic therapy.
摘要
通过对市售的十六氟酞菁锌（II）的外围氟基团进行可控亲核取代反应，合成了一种对称连接有八个硫代葡萄糖单元的水溶性锌（II）酞菁。本文报道了这种不可水解的硫代糖基化酞菁的光物理性质及癌细胞摄取研究。该新化合物具有两亲性，化学性质稳定，有望用作光动力疗法中的光敏剂。
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