Ömeroğlu İpek, Durmuş Mahmut
Department of Chemistry, Faculty of Science, Gebze Technical University, Kocaeli, Turkiye.
Turk J Chem. 2023 Sep 26;47(5):837-863. doi: 10.55730/1300-0527.3583. eCollection 2023.
Photodynamic therapy (PDT) is based on a photochemical reaction that is started when a photosensitizing process is activated by the light and results in the death of tumor cells. Solubility is crucial in PDT applications to investigate the physical and chemical characteristics of phthalocyanines, but, unfortunately, most phthalocyanines show limited solubility especially in water. To increase the solubility of phthalocyanines in polar solvents and water, ionic groups such as -SO, -NR, -COO, and nonionic groups such as polyoxy chains are frequently added to the peripheral or nonperipheral positions of the phthalocyanine framework. Since water-solubility and NIR-absorbing properties are essential for efficient PDT activation, studies have been focused on the synthesis of these types of phthalocyanine derivatives. This review focuses on the photophysical, photochemical, and some in vitro or in vivo studies of the recently published ionic and nonionic phthalocyanine-mediated photosensitizers carried out in the last five years. This review will have positive contributions to future studies on phthalocyanine chemistry and their PDT applications as well as photochemistry.
光动力疗法（PDT）基于一种光化学反应，当光激活光敏过程时该反应启动，并导致肿瘤细胞死亡。在光动力疗法应用中，溶解性对于研究酞菁的物理和化学特性至关重要，但不幸的是，大多数酞菁的溶解性有限，尤其是在水中。为了提高酞菁在极性溶剂和水中的溶解性，常在酞菁骨架的外围或非外围位置添加离子基团，如-SO、-NR、-COO，以及非离子基团，如聚氧链。由于水溶性和近红外吸收特性对于有效的光动力疗法激活至关重要，因此研究集中在这些类型的酞菁衍生物的合成上。本综述重点关注过去五年中发表的离子型和非离子型酞菁介导的光敏剂的光物理、光化学以及一些体外或体内研究。本综述将对酞菁化学及其光动力疗法应用以及光化学的未来研究做出积极贡献。
