Meier D, Wagenaar D J, Chen S, Xu J, Yu J, Tsui B M W
Gamma Medica - Ideas (Norway) AS, Martin Linges Vei 25, Snarøya, POB 1, N-1330 Fornebu, Norway.
Nucl Instrum Methods Phys Res A. 2011 Oct 1;652(1):731-734. doi: 10.1016/j.nima.2010.09.116.
We describe an MR-compatible SPECT camera for small animals. The SPECT camera system can be inserted into the bore of a state-of-the-art MRI system and allows researchers to acquire tomographic images from a mouse in-vivo with the MRI and the SPECT acquiring simultaneously. The SPECT system provides functional information, while MRI provides anatomical information. Until today it was impossible to operate conventional SPECT inside the MRI because of mutual interference. The new SPECT technology is based on semiconductor radiation sensors (CZT, ASICs), and it fits into conventional high field MRI systems with a minimum 12-cm bore size. The SPECT camera has an MR-compatible multi-pinhole collimator for mice with a ø25-mm field-of-view. For the work reported here we assembled a prototype SPECT camera system and acquired SPECT and MRI data from radioactive sources and resolution phantoms using the camera outside and inside the MRI.
我们描述了一种用于小动物的磁共振兼容单光子发射计算机断层显像（SPECT）相机。该SPECT相机系统可插入到最先进的磁共振成像（MRI）系统的孔腔内，使研究人员能够在MRI和SPECT同时采集的情况下，对小鼠进行活体断层成像。SPECT系统提供功能信息，而MRI提供解剖信息。由于相互干扰，此前在MRI内部操作传统SPECT是不可能的。这种新型SPECT技术基于半导体辐射传感器（碲锌镉、专用集成电路），它可适配内径最小为12厘米的传统高场MRI系统。该SPECT相机具有一个用于小鼠的磁共振兼容多孔径准直器，视野为ø25毫米。对于此处报道的工作，我们组装了一个SPECT相机系统原型，并使用该相机在MRI外部和内部，从放射源和分辨率体模获取了SPECT和MRI数据。
