白藜芦醇通过靶向DEPTDOR抑制mTOR信号传导。
Resveratrol inhibits mTOR signaling by targeting DEPTOR.
作者信息
Liu Meilian, Liu Feng
机构信息
Department of Pharmacology; University of Texas Health Science Center; San Antonio, TX USA.
出版信息
Commun Integr Biol. 2011 Jul;4(4):382-4. doi: 10.4161/cib.15309. Epub 2011 Jul 1.
Abstract
Resveratrol (RSV, trans-3,4,5-Trihydroxystilbene), a type of polyphenol originally found in red wines, shows a great promise for the treatment of cancer, aging, type 2 diabetes and cardiovascular diseases. Recent studies suggest that suppressing the signaling pathway mediated by mTOR, a well-known energy sensor that integrates various hormonal, nutrient and environmental signals to regulate cell growth, metabolism and survival, could play an important role in mediating the beneficial effect of RSV. The underlying mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1- and AMPK-independent mechanism. RSV treatment has no effect on the expression levels of mTOR, raptor and DEPTOR, but greatly promotes the interaction between mTOR and its inhibitor DEPTOR. Our results reveal a novel mechanism by which RSV inhibits mTOR signaling and its function.
摘要
白藜芦醇（RSV，反式-3,4,5-三羟基芪）是一种最初在红酒中发现的多酚，在治疗癌症、衰老、2型糖尿病和心血管疾病方面显示出巨大的前景。最近的研究表明，抑制由mTOR介导的信号通路可能在介导RSV的有益作用中发挥重要作用。mTOR是一种著名的能量传感器，它整合各种激素、营养和环境信号来调节细胞生长、代谢和存活。RSV抑制mTOR信号传导的潜在机制仍然不清楚，但我们最近的研究表明，RSV通过一种不依赖Sirt1和AMPK的机制抑制C2C12成纤维细胞中氨基酸刺激的mTOR信号传导。RSV处理对mTOR、 Raptor和DEPTOR的表达水平没有影响，但极大地促进了mTOR与其抑制剂DEPTOR之间的相互作用。我们的结果揭示了RSV抑制mTOR信号传导及其功能的新机制。
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本文引用的文献
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Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR.白藜芦醇通过促进 mTOR 和 DEPTOR 之间的相互作用来抑制 mTOR 信号通路。
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