Nakajima Kenichi, Okuda Koichi, Kawano Masaya, Matsuo Shinro, Slomka Piotr, Germano Guido, Kinuya Seigo
Department of Nuclear Medicine, Kanazawa University Hospital, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.
J Nucl Cardiol. 2009 May-Jun;16(3):422-30. doi: 10.1007/s12350-009-9049-1. Epub 2009 Feb 4.
We aimed to develop a Japanese normal database for specific acquisition conditions, to compare US and Japanese normal populations, and to examine effects of camera rotation angle range on the normal limits.
Stress-rest (99m)Tc myocardial perfusion databases for 360 degrees (Jp360) and 180 degrees (Jp180) acquisitions were created by the working group activity of the Japanese Society of Nuclear Medicine using Japanese patients. A standard 180 degrees database (US180) had been previously generated by the Cedars Sinai Medical Center based on American patients. Additionally, 90 Japanese patients underwent coronary arteriography and stress-rest (99m)Tc perfusion study with 360 degrees acquisition for validation purposes, and quantitative evaluation was performed by QPS software using the above three normal database sets. Major differences between US180 and Jp360 databases were found in the apex and in the anterior wall in females and in the inferior wall in males. When the diagnostic performance was evaluated by receiver-operating characteristic analysis, area under the curve was the highest for Jp360 (0.842), followed by Jp180 (0.758) and US180 (0.728) databases (P = .019, Jp360 vs US180; P = .035, Jp360 vs Jp180). The coronary territory score at stress was highest with the Jp360 database in male patients with right coronary artery stenosis (n = 26, Jp360: 4.92 +/- 4.61 [mean +/- SD], Jp180: 4.23 +/- 4.29, US180: 2.92 +/- 3.53; P < .0001 between Jp360 and US180) and in female patients with left anterior descending artery stenosis (n = 12, Jp360: 6.33 +/- 4.76, Jp180: 5.25 +/- 4.83, US180: 4.50 +/- 4.15; P = .0076 between Jp360 and US180).
Because of the differences between US and Japanese normal databases, it is essential to use population- and acquisition-specific databases when using quantitative perfusion SPECT software.
我们旨在建立一个针对特定采集条件的日本正常数据库，比较美国和日本的正常人群，并研究相机旋转角度范围对正常界限的影响。
日本核医学协会的工作组活动利用日本患者创建了用于360度（Jp360）和180度（Jp180）采集的静息-负荷（99m）Tc心肌灌注数据库。雪松西奈医疗中心此前基于美国患者生成了一个标准的180度数据库（US180）。此外，90名日本患者接受了冠状动脉造影以及静息-负荷（99m）Tc灌注研究，采用360度采集用于验证目的，并使用上述三个正常数据库集通过QPS软件进行定量评估。发现US180和Jp360数据库之间的主要差异在于女性的心尖和前壁以及男性的下壁。当通过受试者操作特征分析评估诊断性能时，曲线下面积以Jp360最高（0.842），其次是Jp180（0.758）和US180（0.728）数据库（P = 0.019，Jp360对比US180；P = 0.035，Jp360对比Jp180）。在右冠状动脉狭窄的男性患者（n = 26，Jp360：4.92±4.61[均值±标准差]，Jp180：4.23±4.29，US180：2.92±3.53；Jp360与US180之间P < 0.0001）和左前降支动脉狭窄的女性患者（n = 12，Jp360：6.33±4.76，Jp180：5.25±4.83，US180：4.50±4.15；Jp360与US180之间P = 0.0076）中，负荷状态下的冠状动脉区域评分以Jp360数据库最高。
由于美国和日本正常数据库之间存在差异，在使用定量灌注SPECT软件时，使用针对特定人群和采集条件的数据库至关重要。
