United Institute of Pharmacy, UCER, Allahabad, India.
Asian Pac J Trop Med. 2011 Sep;4(9):689-93. doi: 10.1016/S1995-7645(11)60175-2.
To evaluate the antihyperglycemic activity of leaves of Hyptis suaveolens using streptozotocin model.
Hyptis suaveolens extract (HSE) 250 and 500 mg/kg body weight was administered orally to streptozotocin induced diabetes, once daily for 21 days.
A significant reduction in blood glucose was observed in diabetic animals treated with HSE at different doses when compared with diabetic rats. Levels of triglyceride, total cholesterol, low density lipoprotein, very low density lipoprotein were decreased while administering HSE at different doses, compared with their control values in diabetic animals.
Our results show that HSE possesses significant antihyperglycemic activity which might be attributed to stimulating effects on glucose utilization and antioxidant enzyme.
评估皱叶酸模叶的降血糖活性，使用链脲佐菌素模型。
皱叶酸模提取物（HSE）250 和 500mg/kg 体重，每日一次，连续 21 天，口服给予链脲佐菌素诱导的糖尿病。
与糖尿病大鼠相比，用不同剂量的 HSE 治疗的糖尿病动物的血糖显著降低。与糖尿病动物的对照值相比，给予不同剂量的 HSE 可降低甘油三酯、总胆固醇、低密度脂蛋白、极低密度脂蛋白的水平。
我们的结果表明，HSE 具有显著的降血糖活性，这可能归因于对葡萄糖利用和抗氧化酶的刺激作用。
