National Heart, Lung, and Blood Institute's Framingham Heart Study, 73 Mt, Wayte Avenue, Suite 2, Framingham, Massachusetts 01702, USA.
BMC Nephrol. 2011 Oct 4;12:52. doi: 10.1186/1471-2369-12-52.
Renal sinus fat may mediate obesity-related vascular disease, although this fat depot has not been assessed in a community-based sample. We sought to develop a protocol to quantify renal sinus fat accumulation using multi-detector computed tomography (MDCT).
Protocol development was performed in participants in the Framingham Offspring cohort who underwent MDCT. Volumetric renal sinus fat was measured separately within the right and left kidneys, and renal sinus fat area within a single MDCT scan slice was measured in the right kidney. Due to the high correlation of volumetric and single-slice renal sinus fat in the right kidney (Pearson correlation [r] = 0.85, p < 0.0001), we optimized a single-slice protocol to capture renal sinus fat in the right kidney alone. Pearson correlation coefficients were used to compare to assess the correlation of volumetric and single-slice renal sinus fat in the right kidney with other measures of adiposity. Inter- and intra-reader reproducibility was assessed using intra-class correlation coefficients.
Single-slice measurements were obtained in 92 participants (mean age 60 years, 49% women, median renal sinus fat 0.43 cm2). Intra- and inter-reader intra-class correlation coefficients were 0.93 and 0.86, respectively. Single-slice renal sinus fat was correlated with body mass index (r = 0.35, p = 0.0006), waist circumference (r = 0.31, p = 0.003), and abdominal visceral fat (r = 0.48, p < 0.0001). Similar correlations were observed for volumetric renal sinus fat in the right kidney.
Measuring renal sinus fat is feasible and reproducible using MDCT scans in a community-based sample.
肾窦脂肪可能介导肥胖相关的血管疾病，尽管尚未在基于社区的样本中评估该脂肪库。我们试图制定一种使用多探测器 CT（MDCT）量化肾窦脂肪堆积的方案。
在 Framingham 后代队列的参与者中进行方案开发，这些参与者接受了 MDCT 检查。分别测量右肾和左肾的肾窦脂肪容积，在右肾的单次 MDCT 扫描片中测量肾窦脂肪面积。由于右肾容积和单切片肾窦脂肪之间具有很高的相关性（Pearson 相关系数[r] = 0.85，p <0.0001），因此我们优化了单切片方案，仅捕获右肾的肾窦脂肪。使用 Pearson 相关系数来评估右肾容积和单切片肾窦脂肪与其他肥胖指标的相关性。使用组内相关系数评估读者间和读者内的可重复性。
在 92 名参与者（平均年龄 60 岁，49%为女性，中位数肾窦脂肪 0.43 cm2）中获得了单切片测量值。读者内和读者间的组内相关系数分别为 0.93 和 0.86。单切片肾窦脂肪与体重指数（r = 0.35，p = 0.0006）、腰围（r = 0.31，p = 0.003）和腹部内脏脂肪（r = 0.48，p <0.0001）相关。类似的相关性也存在于右肾的容积肾窦脂肪中。
在基于社区的样本中，使用 MDCT 扫描测量肾窦脂肪是可行且可重复的。
