Department of Pediatrics, Johns Hopkins University, School of Medicine, 200 North Wolfe Street, Baltimore, MD 21287, USA.
Matern Child Health J. 2012 Aug;16(6):1304-11. doi: 10.1007/s10995-011-0892-8.
Symptoms of depression and anxiety are prevalent during pregnancy and may influence women's health behaviors. The impact of women's mental health on alcohol use may be particularly important to consider as prenatal alcohol use is common and may have serious negative consequences for the developing fetus. The objectives of this study were to investigate the relationships between elevated symptoms of depression and anxiety and subsequent likelihood of any alcohol use and binge drinking during pregnancy. The sample consisted of 12,824 women from a prospective, population-based study from the United Kingdom, the Avon Longitudinal Study of Parents and Children. Participants completed questionnaires assessing alcohol use and depressive and anxious symptoms during the first and third trimesters of pregnancy. A series of multivariable regression models was fit using multiply imputed data. Thirty four percent of women reported having at least one alcoholic drink at 32 weeks' gestation and 17% reported binge drinking. We found a weak association between elevated symptoms of anxiety and any alcohol use but not between elevated symptoms of depression and any alcohol use. Modest associations were found between both elevated symptoms of depression and anxiety at 18 weeks' gestation and binge drinking at 32 weeks' gestation. Elevated symptoms of depression and anxiety may increase risk for binge drinking during pregnancy. Further research into the impact of symptoms of depression and anxiety on binge drinking during pregnancy is needed as this could represent an opportunity for public health intervention.
怀孕期间抑郁和焦虑症状普遍存在，可能会影响女性的健康行为。考虑到女性的心理健康对酒精使用的影响可能尤为重要，因为产前饮酒很常见，并且可能对发育中的胎儿产生严重的负面影响。本研究的目的是调查抑郁和焦虑症状加重与随后任何孕期饮酒和 binge drinking 的发生几率之间的关系。该样本由来自英国的一项前瞻性、基于人群的研究（Avon Longitudinal Study of Parents and Children）中的 12824 名女性组成。参与者在怀孕的第一和第三个三个月期间完成了评估酒精使用和抑郁及焦虑症状的问卷。使用多重插补数据拟合了一系列多变量回归模型。34%的女性报告在 32 周妊娠时至少喝了一杯含酒精的饮料，17%的女性报告 binge drinking。我们发现焦虑症状加重与任何饮酒之间存在微弱的关联，但抑郁症状加重与任何饮酒之间不存在关联。在 18 周妊娠时抑郁和焦虑症状加重均与 32 周妊娠时 binge drinking 之间存在适度的关联。抑郁和焦虑症状加重可能会增加孕期 binge drinking 的风险。需要进一步研究抑郁和焦虑症状对孕期 binge drinking 的影响，因为这可能代表公共卫生干预的机会。
