Riedel D, Lindemann A, Brach M, Mertelsmann R, Herrmann F
Department of Hematology and Oncology, University of Freiburg, FRG.
Immunology. 1990 Jun;70(2):258-61.
In this report it is shown by immunofluorescence analysis, biochemical analysis and mRNA hybridization that human eosinophils express surface CD4 and interleukin-2 receptor (IL-2R) (CD25) when exposed to eosinophil activators granulocyte-macrophage colony-stimulating factor (GM-CSF) and IL-3. Although the functional role of eosinophil CD4/CD25 expression has to be elucidated, it will be of interest in further studies to investigate whether in vivo induction of these molecules occurs in association with certain disease processes such as the hypereosinophilic syndrome or in immunological responses during allergic and helminthic parasitic diseases.
在本报告中，通过免疫荧光分析、生化分析和mRNA杂交表明，当人类嗜酸性粒细胞暴露于嗜酸性粒细胞激活剂粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-3（IL-3）时，其表达表面CD4和白细胞介素-2受体（IL-2R）（CD25）。尽管嗜酸性粒细胞CD4/CD25表达的功能作用有待阐明，但在进一步研究中，探究这些分子在体内的诱导是否与某些疾病过程相关，如高嗜酸性粒细胞综合征，或与过敏性和蠕虫寄生虫病期间的免疫反应相关，将是很有意义的。
