γ干扰素诱导的人白血病及正常单核细胞中白细胞介素2受体的表达及白细胞介素2的结合
Expression of interleukin 2 receptors and binding of interleukin 2 by gamma interferon-induced human leukemic and normal monocytic cells.
作者信息
Herrmann F, Cannistra S A, Levine H, Griffin J D
出版信息
J Exp Med. 1985 Sep 1;162(3):1111-6. doi: 10.1084/jem.162.3.1111.
Abstract
Gamma interferon induced surface expression of interleukin 2 (IL-2) receptors on normal human monocytes and the monocytoid cell lines U937 and HL60. These receptors were detected by anti-IL-2 receptor monoclonal antibodies, and U937 IL-2 receptors were indistinguishable from T lymphocyte IL-2 receptors by immunoprecipitation. Also, U937 IL-2 receptors bound biologically active IL-2. These results suggest a role for monocyte IL-2 receptors in T cell/monocyte interaction during an immune response.
摘要
γ干扰素可诱导正常人单核细胞以及单核细胞样细胞系U937和HL60表面表达白细胞介素2（IL-2）受体。这些受体通过抗IL-2受体单克隆抗体进行检测，并且通过免疫沉淀法发现U937细胞的IL-2受体与T淋巴细胞的IL-2受体难以区分。此外，U937细胞的IL-2受体可结合具有生物活性的IL-2。这些结果表明单核细胞IL-2受体在免疫应答过程中的T细胞/单核细胞相互作用中发挥作用。
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本文引用的文献
1
2
3
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J Exp Med. 1983 Dec 1;158(6):2058-80. doi: 10.1084/jem.158.6.2058.
4
Prostaglandins modulate macrophage Ia expression.前列腺素调节巨噬细胞Ia抗原的表达。
Nature. 1982 Sep 9;299(5879):163-5. doi: 10.1038/299163a0.
5
Ta1, a novel 105 KD human T cell activation antigen defined by a monoclonal antibody.Ta1，一种由单克隆抗体定义的新型105千道尔顿人类T细胞活化抗原。
J Immunol. 1984 Sep;133(3):1250-6.
6
7
Detection and functional studies of p60-65 (Tac antigen) on activated human B cells.活化人B细胞上p60 - 65（Tac抗原）的检测及功能研究
J Exp Med. 1984 Nov 1;160(5):1597-602. doi: 10.1084/jem.160.5.1597.
8
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J Exp Med. 1984 Nov 1;160(5):1450-66. doi: 10.1084/jem.160.5.1450.
9
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