Maskell D J, Hormaeche C E
J Immunogenet. 1986 Oct-Dec;13(5-6):451-7. doi: 10.1111/j.1744-313x.1986.tb01129.x.
Control by genes within H-2 of natural resistance to fully virulent salmonellae in susceptible mice was studied by the typhoid relapse model. Susceptible (Itys), H-2 congenic C57BL/10 (B10) lines were infected with a lethal dose of the virulent S. typhimurium C5 and rescued from death by ampicillin therapy, inducing a chronic infection. The response to therapy and its cessation, both early and late in the infection, varied in different strains. B10 (H-2b) and B10.D2 (H-2d) responded less well to therapy, and were more prone to relapse on its removal, than B10.A (H-2a) or B10.M (H-2f) mice. This haplotype distribution is the same as that previously reported for H-2 linked resistance and susceptibility of similar mice to salmonellae of low virulence. The results indicate that resistance to a virulent salmonella capable of causing natural infection is influenced by genes within the MHC.
通过伤寒复发模型研究了H-2基因对易感小鼠中对完全毒力沙门氏菌天然抵抗力的控制。易感（Itys）、H-2同基因C57BL/10（B10）品系用致死剂量的毒力鼠伤寒沙门氏菌C5感染，并通过氨苄青霉素治疗从死亡中挽救过来，从而引发慢性感染。在感染的早期和晚期，不同品系对治疗及其停止的反应各不相同。与B10.A（H-2a）或B10.M（H-2f）小鼠相比，B10（H-2b）和B10.D2（H-2d）对治疗的反应较差，并且在停止治疗后更容易复发。这种单倍型分布与先前报道的H-2连锁的类似小鼠对低毒力沙门氏菌的抗性和易感性相同。结果表明，对能够引起自然感染的毒力沙门氏菌的抗性受MHC内基因的影响。
