Department of Epidemiology and Psychiatry, Columbia University, New York City, New York 10032, USA.
Subst Use Misuse. 2011;46(14):1716-25. doi: 10.3109/10826084.2011.611960. Epub 2011 Oct 5.
The sample included 343 opioid-dependent adults enrolled in two national multisite studies of the National Drug Abuse Treatment Clinical Trials Network (CTN001-002). Opioid-dependent individuals were recruited from 12 sites across the United States from January 2001 to July 2002. We examined associations between depressive symptoms, co-occurring substance use (i.e., the use of substances other than opioids), and HIV-related sexual and injection risk behaviors. Data were collected using the Addiction Severity Index and the HIV Risk Behavior Scale, and analyzed using linear regression. Depressive symptoms were associated with an increased level of injection risk behaviors but were not associated with risky sexual behaviors. The co-occurring use of amphetamines also increased the likelihood of risky sexual behaviors. The study limitations and clinical implications are noted. The study was funded by the U.S. National Institute on Drug Abuse.
本研究纳入了 343 名阿片类药物依赖的成年人，他们参与了美国国家药物滥用治疗临床试验网络（CTN001-002）的两项全国多中心研究。阿片类药物依赖个体于 2001 年 1 月至 2002 年 7 月期间从美国 12 个研究点招募而来。我们研究了抑郁症状、共病物质使用（即使用阿片类药物以外的物质）与 HIV 相关的性和注射风险行为之间的关系。研究使用成瘾严重程度指数和 HIV 风险行为量表收集数据，并使用线性回归进行分析。抑郁症状与注射风险行为水平的增加相关，但与高危性行为无关。同时使用安非他命也增加了高危性行为的可能性。本研究还讨论了其局限性和临床意义。本研究由美国国立药物滥用研究所资助。
