Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany.
Am J Clin Nutr. 2011 Dec;94(6 Suppl):1749S-1753S. doi: 10.3945/ajcn.110.000471. Epub 2011 Oct 5.
Differences in nutritional experiences during sensitive periods in early life, both before and after birth, can program a person's future development, metabolism, and health. A better scientific understanding of early nutrition programming holds enormous potential for implementing preventive strategies to enhance individuals' long-term health, well-being, and performance. This understanding could reduce costs of health care and social services and may enhance the wealth of societies. The Early Nutrition Programming Project (EARNEST) brought together a multidisciplinary team of international scientists and leaders in key areas of the early nutrition programming field from 40 major research centers across 16 European countries. The project had a total budget of 16.5 million Euros and was funded by the European Communities under the Sixth Framework Program for Research and Technical Development and coordinated by the Children's Hospital at Ludwig-Maximilians-University of Munich. The integrated program of work combined experimental studies in humans, prospective observational studies, and mechanistic animal work, including physiologic studies, cell culture models, and molecular biology techniques. The project lasted from April 2005 to October 2010. After the end of the project, the Early Nutrition Academy (http://www.early-nutrition.org) continues to serve as a platform for the exchange of information, scientific collaboration, and training activities in the area of programming. This article highlights some of the scientific results, achievements, and efforts of EARNEST.
在生命早期的敏感时期，无论是出生前还是出生后，营养体验的差异都可能影响一个人的未来发育、代谢和健康。更好地了解早期营养编程具有实施预防策略的巨大潜力，可以增强个体的长期健康、幸福和表现。这种理解可以降低医疗保健和社会服务的成本，并可能提高社会的财富。早期营养编程项目（EARNEST）汇集了来自 16 个欧洲国家的 40 个主要研究中心的国际科学家和关键领域的早期营养编程领域的领导者组成的多学科团队。该项目总预算为 1650 万欧元，由欧洲共同体在第六个研究和技术发展框架计划下资助，由慕尼黑路德维希-马克西米利安大学儿童医院协调。该综合工作计划结合了人体实验研究、前瞻性观察研究和机制动物研究，包括生理学研究、细胞培养模型和分子生物学技术。该项目于 2005 年 4 月至 2010 年 10 月进行。项目结束后，早期营养学院（http://www.early-nutrition.org）继续作为该领域编程信息交流、科学合作和培训活动的平台。本文重点介绍了 EARNEST 的一些科学成果、成就和努力。
