Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Cancer Epidemiol Biomarkers Prev. 2011 Dec;20(12):2507-11. doi: 10.1158/1055-9965.EPI-11-0721. Epub 2011 Oct 5.
The major health benefit of exposure to solar UV radiation is the production of vitamin D, which is implicated in protection against several human cancers, including ovarian carcinoma. On the other hand, solar UV radiation is a recognized risk factor for cataract.
This population-based case-control study of 709 women with primary invasive ovarian carcinoma and 1,101 controls examined the association of ovarian carcinoma risk with self-reported history of cataract as an indicator of high long-term exposure to UV radiation. ORs and 95% confidence intervals (CI) were estimated using multivariate logistic regression models.
Among controls, older age (P < 0.0001), history of type 2 diabetes (P = 0.04), and skin cancer (P = 0.03) were significant cataract risk predictors. A history of cataract, reported by 14% of cases and 17% of controls, was significantly associated with a reduced ovarian carcinoma risk (OR = 0.6; 95% CI, 0.4-0.8; P = 0.002). No heterogeneity was observed by tumor histology, stage, grade, study site, body mass index, or other ovarian cancer risk factors (P > 0.16).
These findings add indirect evidence to the hypothesis that lifetime vitamin D exposure may be inversely associated with risk of ovarian carcinoma.
The study suggests some potential new avenues for research. Additional studies are needed to further investigate the potential behavioral and biologic factors that might influence association of cataract with ovarian cancer.
暴露于太阳紫外线辐射的主要健康益处是产生维生素 D，维生素 D 被认为可预防包括卵巢癌在内的多种人类癌症。另一方面，太阳紫外线辐射是白内障的公认危险因素。
这项基于人群的病例对照研究共纳入 709 名原发性浸润性卵巢癌患者和 1101 名对照，研究了卵巢癌风险与白内障自述史（作为长期高剂量紫外线辐射暴露的指标）之间的关联。使用多变量逻辑回归模型估计了比值比（OR）和 95%置信区间（CI）。
在对照组中，年龄较大（P < 0.0001）、2 型糖尿病史（P = 0.04）和皮肤癌史（P = 0.03）是白内障的显著风险预测因素。病例组中有 14%和对照组中有 17%报告了白内障史，与卵巢癌风险降低显著相关（OR = 0.6；95%CI，0.4-0.8；P = 0.002）。未观察到肿瘤组织学、分期、分级、研究地点、体重指数或其他卵巢癌危险因素存在异质性（P > 0.16）。
这些发现为维生素 D 暴露可能与卵巢癌风险呈负相关的假说提供了间接证据。
该研究为进一步研究提供了一些新的潜在途径。需要进一步研究潜在的行为和生物学因素，以进一步调查白内障与卵巢癌之间的关联。
